A review of intralesional wart therapy.
Aminolevulinic Acid
/ administration & dosage
Anti-Bacterial Agents
/ administration & dosage
Antiviral Agents
/ administration & dosage
BCG Vaccine
/ administration & dosage
Bacterial Vaccines
/ administration & dosage
Humans
Injections, Intralesional
Interferon-alpha
/ administration & dosage
Mycobacterium
Tuberculin
/ administration & dosage
Vitamin D
/ administration & dosage
Warts
/ drug therapy
Journal
Dermatology online journal
ISSN: 1087-2108
Titre abrégé: Dermatol Online J
Pays: United States
ID NLM: 9610776
Informations de publication
Date de publication:
15 Mar 2020
15 Mar 2020
Historique:
received:
04
05
2020
accepted:
04
05
2020
entrez:
2
7
2020
pubmed:
2
7
2020
medline:
11
7
2020
Statut:
epublish
Résumé
New treatment options for warts include intralesional wart injection with agents such as vitamin D, measles, mumps, and rubella (MMR) vaccine antigen, Bacillus Calmette-Guerin (BCG) antigen, and candida antigen but there have been limited studies to compare their efficacies. The purpose of this systematic review is to compare the efficacy and safety of injectable agents used for the treatment of warts. A PubMed search included terms "intralesional wart therapy," "wart injection" and "verruca injection." Articles reviewed were published over 10 years. A total of 43 articles were reviewed; 30 covered studies with more than 10 participants and 13 were case reports, case series, and reviews. In comparison studies intralesional agents have equal or superior efficacy (66%-94.9%) compared to first-line salicylic acid or cryotherapy (65.5-76.5%). One advantage of intralesional injections is the rate of complete resolution of distant warts. Each study varied in their agents, treatment interval, and treatment dose, making comparisons difficult. Intralesional wart injections are safe, affordable, and efficacious treatments for warts. Physicians should consider intralesional injections for patients with refractory warts, multiple warts, or warts in sensitive areas.
Sections du résumé
BACKGROUND
BACKGROUND
New treatment options for warts include intralesional wart injection with agents such as vitamin D, measles, mumps, and rubella (MMR) vaccine antigen, Bacillus Calmette-Guerin (BCG) antigen, and candida antigen but there have been limited studies to compare their efficacies.
OBJECTIVE
OBJECTIVE
The purpose of this systematic review is to compare the efficacy and safety of injectable agents used for the treatment of warts.
METHODS
METHODS
A PubMed search included terms "intralesional wart therapy," "wart injection" and "verruca injection." Articles reviewed were published over 10 years.
RESULTS
RESULTS
A total of 43 articles were reviewed; 30 covered studies with more than 10 participants and 13 were case reports, case series, and reviews. In comparison studies intralesional agents have equal or superior efficacy (66%-94.9%) compared to first-line salicylic acid or cryotherapy (65.5-76.5%). One advantage of intralesional injections is the rate of complete resolution of distant warts.
LIMITATIONS
CONCLUSIONS
Each study varied in their agents, treatment interval, and treatment dose, making comparisons difficult.
CONCLUSIONS
CONCLUSIONS
Intralesional wart injections are safe, affordable, and efficacious treatments for warts. Physicians should consider intralesional injections for patients with refractory warts, multiple warts, or warts in sensitive areas.
Substances chimiques
Anti-Bacterial Agents
0
Antiviral Agents
0
BCG Vaccine
0
Bacterial Vaccines
0
Interferon-alpha
0
Tuberculin
0
Vitamin D
1406-16-2
Aminolevulinic Acid
88755TAZ87
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM