Effects of metabolic state on the regulation of melanocortin circuits.
Journal
Physiology & behavior
ISSN: 1873-507X
Titre abrégé: Physiol Behav
Pays: United States
ID NLM: 0151504
Informations de publication
Date de publication:
01 10 2020
01 10 2020
Historique:
received:
20
12
2019
revised:
01
06
2020
accepted:
26
06
2020
pubmed:
2
7
2020
medline:
22
6
2021
entrez:
2
7
2020
Statut:
ppublish
Résumé
Dysfunction in neurophysiological systems that regulate food intake and metabolism are at least partly responsible for obesity and related comorbidities. An important component of this process is the hypothalamic melanocortin system, where an imbalance can result in severe obesity and deficits in glucose metabolism. Exercise offers many health benefits related to cardiovascular improvements, hunger control, and blood glucose homeostasis. However, the molecular mechanism underlying the exercise-induced improvements to the melanocortin system remain undefined. Here, we review the role of the melanocortin system to sense hormonal, nutrient, and neuronal signals of energy status. This information is then relayed onto secondary neurons in order to regulate physiological parameters, which promote proper energy and glucose balance. We also provide an overview on the effects of physical exercise to induce biophysical changes in the melanocortin circuit which may regulate food intake, glucose metabolism and improve overall metabolic health.
Identifiants
pubmed: 32610101
pii: S0031-9384(20)30353-X
doi: 10.1016/j.physbeh.2020.113039
pmc: PMC7387173
mid: NIHMS1609696
pii:
doi:
Substances chimiques
Melanocortins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
113039Subventions
Organisme : NIDDK NIH HHS
ID : P01 DK119130
Pays : United States
Organisme : NIDDK NIH HHS
ID : R00 DK119574
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK119169
Pays : United States
Organisme : NIDDK NIH HHS
ID : K99 DK119574
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK114014
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK100699
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have nothing to disclose.
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