Proinflammatory α-Adrenergic Neuronal Regulation of Splenic IFN-γ, IL-6, and TGF-β of Mice from Day 15 onwards in Arthritis.
Arthritis
Cytokine regulation
Nerve fiber loss
Spleen
Sympathetic nervous system
Journal
Neuroimmunomodulation
ISSN: 1423-0216
Titre abrégé: Neuroimmunomodulation
Pays: Switzerland
ID NLM: 9422763
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
03
2020
accepted:
19
04
2020
pubmed:
2
7
2020
medline:
27
7
2021
entrez:
2
7
2020
Statut:
ppublish
Résumé
In arthritic mice, a sympathetic influence is proinflammatory from the time point of immunization until the onset of disease (days 0-32), but reasons are unknown. Disruption of the major anti-inflammatory pathway through Gαs-coupled receptors probably play a role. For example, noradrenaline cannot operate via anti-inflammatory β2-adrenoceptors but through proinflammatory α1/2-ad-renoceptors. This might happen, first, through a loss of sympathetic nerve fibers in inflamed tissue with low neurotransmitter levels (noradrenaline only binds to high-affinity α-adrenoceptors) and, second, through an alteration in G-protein receptor coupling with a predominance of α-adrenergic signaling. We hypothesized that both mechanisms play a role in the course of collagen type II-induced arthritis (CIA) in the spleen in mice. In CIA mice, nerve fiber density in the spleen was quantified by immunohistochemistry techniques. The functional impact of sympathetic nerve fibers in the spleen was studied by a micro-superfusion technique of spleen slices with a focus on the secretion of IFN-γ and IL-6 (proinflammatory) and TGF-β (anti-inflammatory). During CIA, sympathetic nerve fibers get increasingly lost from day14 until day 55 after immunization. The influence of electrically released noradrenaline diminishes in the course of arthritis. At all investigated time points (days 14, 32, and 55), only proinflammatory neuronal α-adrenergic effects on cytokine secretion were demonstrated (i.e., stimulation of IFN-γ and IL-6 and inhibition of TGF-β). Sympathetic nerve fibers are rapidly lost in the spleen, and only proinflammatory α-adrenergic neuronal regulation of cytokine secretion takes place throughout the course of arthritis. These results support a predominance of a proinflammatory α-adrenergic sympathetic influence in arthritis.
Identifiants
pubmed: 32610310
pii: 000508109
doi: 10.1159/000508109
pmc: PMC7446300
doi:
Substances chimiques
Interleukin-6
0
Transforming Growth Factor beta
0
interleukin-6, mouse
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
58-68Informations de copyright
© 2020 The Author(s) Published by S. Karger AG, Basel.
Références
Brain Behav Immun. 2011 Nov;25(8):1708-15
pubmed: 21767631
Life Sci. 2017 Jan 1;168:47-53
pubmed: 27856318
J Exp Med. 1995 Feb 1;181(2):775-9
pubmed: 7836930
J Pharmacol Exp Ther. 1995 Mar;272(3):1313-20
pubmed: 7891349
J Immunol. 1997 May 1;158(9):4200-10
pubmed: 9126981
Brain Behav Immun. 2013 Oct;33:80-9
pubmed: 23791889
Infect Immun. 1994 May;62(5):2046-50
pubmed: 8168970
Rheum Dis Clin North Am. 1987 Aug;13(2):369-83
pubmed: 2447613
Ann Rheum Dis. 2010 Sep;69(9):1717-23
pubmed: 20511609
Br Med J. 1967 Jul 1;3(5556):26-8
pubmed: 6027379
J Rheumatol. 1997 Dec;24(12):2476-8
pubmed: 9415662
Brain Behav Immun. 2016 May;54:201-210
pubmed: 26872423
Immunol Res. 2014 May;58(2-3):193-210
pubmed: 24798553
Clin Rheumatol. 2018 Apr;37(4):943-948
pubmed: 29335897
Md State Med J. 1972 Mar;21(3):38-42
pubmed: 5010906
Brain Behav Immun. 2015 Nov;50:266-274
pubmed: 26212359
Prog Brain Res. 1996;113:161-84
pubmed: 9009734
Arthritis Rheum. 2012 Apr;64(4):1110-8
pubmed: 22034154
Circ Res. 2007 Apr 13;100(7):950-66
pubmed: 17431197
Int J Mol Sci. 2015 Mar 11;16(3):5635-65
pubmed: 25768345
Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):940-5
pubmed: 12552097
J Immunol. 1988 Oct 1;141(7):2388-93
pubmed: 2844899
Immunity. 2018 Jul 17;49(1):93-106.e7
pubmed: 29958804
Ann Rheum Dis. 2004 Oct;63(10):1349-51
pubmed: 15361401
Ann Rheum Dis. 1976 Dec;35(6):534-5
pubmed: 1008622
Arthritis Res Ther. 2014;16(6):504
pubmed: 25789375
Arthritis Rheum. 2008 Nov;58(11):3450-60
pubmed: 18975332
J Immunol. 1994 Mar 15;152(6):3024-31
pubmed: 8144901
Brain Behav Immun. 2009 Feb;23(2):276-85
pubmed: 18984038
J Can Assoc Radiol. 1983 Mar;34(1):49-50
pubmed: 6841420
Proc Natl Acad Sci U S A. 1988 Jun;85(12):4553-6
pubmed: 2837769
Ryumachi. 1994 Jun;34(3):656-61
pubmed: 8052933
Neuroscience. 1993 Feb;52(3):735-43
pubmed: 8450970
Br J Rheumatol. 1993 May;32(5):413-6
pubmed: 7684307
Ann Rheum Dis. 2015 Feb;74(2):444-51
pubmed: 24297380
Science. 1984 Nov 2;226(4674):547-9
pubmed: 6208609
Res Publ Assoc Res Nerv Ment Dis. 1949 Dec;29:3-18
pubmed: 14854281
Arthritis Rheum. 1979 Dec;22(12):1419-20
pubmed: 518728
Proc Assoc Am Physicians. 1996 Sep;108(5):374-81
pubmed: 8902882
Auton Neurosci. 2014 May;182:55-64
pubmed: 24423405
Brain Behav Immun. 2017 Aug;64:330-343
pubmed: 28392428
Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8284-9
pubmed: 27382171
Inflamm Res. 2018 Feb;67(2):157-168
pubmed: 29022064
J Neuroimmunol. 1995 Aug;61(1):53-60
pubmed: 7560012
Arthritis Rheum. 2003 Dec;48(12):3557-67
pubmed: 14674009
Ann Rheum Dis. 2005 Jan;64(1):13-20
pubmed: 15608299
J Allergy Clin Immunol. 2000 Jan;105(1 Pt 1):91-8
pubmed: 10629458
Brain Behav Immun. 2004 Nov;18(6):563-71
pubmed: 15331127
Ann Rheum Dis. 1962 Dec;21:370-7
pubmed: 13981183
Nat Rev Rheumatol. 2013 Feb;9(2):117-26
pubmed: 23147892
Arthritis Rheum. 2005 Apr;52(4):1305-13
pubmed: 15818682
Int J Mol Sci. 2018 Apr 13;19(4):
pubmed: 29652832