Special Issue on "The Tight Junction and Its Proteins: More than Just a Barrier".
angulin
cancer
cell polarity
claudin
environmental sensors
immune cells
occludin
paracellular channels and barriers
pathogens
tight junction
tricellulin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Jun 2020
29 Jun 2020
Historique:
received:
22
06
2020
accepted:
26
06
2020
entrez:
3
7
2020
pubmed:
3
7
2020
medline:
20
2
2021
Statut:
epublish
Résumé
For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ-mainly, the two families of claudins and TAMPs-several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue covers numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, the function of and regulation by proteins of the tricellular TJ, the TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJs as sensors and reactors to environmental conditions, and last, but not least, TJ proteins and cancer. It is not surprising that due to this diversity of topics and functions, the still-young field of TJ research is growing fast. This Editorial gives an introduction to all 43 papers of the Special Issue in a structured topical order.
Identifiants
pubmed: 32610530
pii: ijms21134612
doi: 10.3390/ijms21134612
pmc: PMC7370070
pii:
doi:
Substances chimiques
Claudins
0
Occludin
0
Tight Junction Proteins
0
Types de publication
Editorial
Introductory Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK 2318, A3 and C2
Organisme : Deutsche Forschungsgemeinschaft
ID : TRR 241, B06
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