The Potential Effect of Aberrant Testosterone Levels on Common Diseases: A Mendelian Randomization Study.
Alzheimer Disease
/ blood
Arthritis
/ blood
Depression
/ blood
Diabetes Mellitus, Type 2
/ blood
Humans
Jumonji Domain-Containing Histone Demethylases
/ genetics
Male
Mendelian Randomization Analysis
Oxidoreductases, N-Demethylating
/ genetics
Polymorphism, Single Nucleotide
Schizophrenia
/ blood
Sex Hormone-Binding Globulin
/ genetics
Testosterone
/ blood
Alzheimer’s Disorder (AD)
Gout
Mendelian Randomization (MR)
Schizophrenia (SCZ)
Testosterone
Type II Diabetes (T2D)
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
29 06 2020
29 06 2020
Historique:
received:
08
06
2020
revised:
21
06
2020
accepted:
26
06
2020
entrez:
3
7
2020
pubmed:
3
7
2020
medline:
19
3
2021
Statut:
epublish
Résumé
Testosterone has historically been linked to sexual dysfunction; however, it has recently been shown to affect other physical and mental attributes. We attempted to determine whether changes in serum testosterone could play a role in chronic or degenerative diseases. We used two separate genetic instruments comprising of variants from
Identifiants
pubmed: 32610558
pii: genes11070721
doi: 10.3390/genes11070721
pmc: PMC7397292
pii:
doi:
Substances chimiques
SHBG protein, human
0
Sex Hormone-Binding Globulin
0
Testosterone
3XMK78S47O
JMJD1C protein, human
EC 1.14.11.-
Jumonji Domain-Containing Histone Demethylases
EC 1.14.11.-
Oxidoreductases, N-Demethylating
EC 1.5.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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