Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines.
CTV
MR guided RT
SBRT
SIB
guidelines
immunotherapy
pancreatic cancer
protons
radiotherapy
review
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
29 Jun 2020
29 Jun 2020
Historique:
received:
26
04
2020
revised:
11
06
2020
accepted:
17
06
2020
entrez:
3
7
2020
pubmed:
3
7
2020
medline:
3
7
2020
Statut:
epublish
Résumé
Pancreatic cancer represents a modern oncological urgency. Its management is aimed to both distal and local disease control. Resectability is the cornerstone of treatment aim. It influences the clinical presentation's definitions as up-front resectable, borderline resectable and locally advanced (unresectable). The main treatment categories are neoadjuvant (preoperative), definitive and adjuvant (postoperative). This review will focus on i) the current indications by the available national and international guidelines; ii) the current standard indications for target volume delineation in radiotherapy (RT); iii) the emerging modern technologies (including particle therapy and Magnetic Resonance [MR]-guided-RT); iv) stereotactic body radiotherapy (SBRT), as the most promising technical delivery application of RT in this framework; v) a particularly promising dose delivery technique called simultaneous integrated boost (SIB); and vi) a multimodal integration opportunity: the combination of RT with immunotherapy.
Identifiants
pubmed: 32610592
pii: cancers12071729
doi: 10.3390/cancers12071729
pmc: PMC7407382
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Déclaration de conflit d'intérêts
Siegel, R.L.; Miller, K.D.; Jemal, A. Cancer statistics, 2019. CA Cancer J. Clin. 2019, 69, 7–34, doi:10.3322/caac.21551.
Références
Radiother Oncol. 2017 Jun;123(3):438-445
pubmed: 28464997
Cureus. 2018 Apr 5;10(4):e2434
pubmed: 29876156
J Gastrointest Surg. 2006 Apr;10(4):511-8
pubmed: 16627216
J Pain Res. 2018 Oct 04;11:2169-2178
pubmed: 30323651
Ann Surg Oncol. 2006 Aug;13(8):1035-46
pubmed: 16865597
Radiother Oncol. 2019 Mar;132:16-22
pubmed: 30825964
Radiat Oncol. 2012 Jun 12;7:86
pubmed: 22691275
J Clin Oncol. 2009 Apr 10;27(11):1806-13
pubmed: 19273710
Semin Oncol. 2015 Feb;42(1):144-62
pubmed: 25726059
Pract Radiat Oncol. 2019 Sep - Oct;9(5):322-332
pubmed: 31474330
PLoS One. 2019 Apr 12;14(4):e0214970
pubmed: 30978229
Oncotarget. 2016 Jul 12;7(28):43039-43051
pubmed: 27343548
Cureus. 2018 Mar 14;10(3):e2324
pubmed: 29765792
Radiother Oncol. 2018 Mar;126(3):519-526
pubmed: 29277446
EMBO Mol Med. 2017 Feb;9(2):167-180
pubmed: 27932443
Br J Radiol. 2018 Nov;91(1091):20170563
pubmed: 30063383
Int J Radiat Oncol Biol Phys. 2014 Nov 15;90(4):918-25
pubmed: 25585785
Int J Radiat Oncol Biol Phys. 2014 Nov 15;90(4):911-7
pubmed: 25220717
Dig Liver Dis. 2018 Dec;50(12):1257-1271
pubmed: 30219670
Adv Radiat Oncol. 2017 Mar 18;2(3):403-415
pubmed: 29114609
Lancet. 2016 Jul 2;388(10039):73-85
pubmed: 26830752
Ann Surg Oncol. 2013 Aug;20(8):2787-95
pubmed: 23435609
Cancer Med. 2019 May;8(5):2123-2132
pubmed: 30932367
Acta Oncol. 2019 Apr;58(4):439-447
pubmed: 30632876
Onco Targets Ther. 2015 Jun 12;8:1427-31
pubmed: 26109866
Br J Surg. 2004 May;91(5):586-94
pubmed: 15122610
Radiat Oncol. 2013 Oct 31;8:254
pubmed: 24175982
Int J Radiat Oncol Biol Phys. 2010 Feb 1;76(2):326-32
pubmed: 20117285
Radiat Oncol. 2014 Sep 08;9:198
pubmed: 25199768
Pancreas. 2008 Jan;36(1):e26-32
pubmed: 18192876
Radiother Oncol. 2015 Jan;114(1):109-16
pubmed: 25466369
Ann Surg Oncol. 2014 Apr;21(4):1064-6
pubmed: 24522986
Crit Rev Oncol Hematol. 2010 Feb;73(2):111-25
pubmed: 19409808
Int J Radiat Oncol Biol Phys. 2012 Nov 1;84(3):e291-7
pubmed: 22682806
Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20212-7
pubmed: 24277834
Ann Surg. 2001 Dec;234(6):758-68
pubmed: 11729382
Chin Clin Oncol. 2017 Jun;6(3):28
pubmed: 28705005
Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2):296-303
pubmed: 27475674
World J Gastrointest Oncol. 2015 Sep 15;7(9):141-7
pubmed: 26380057
J Oncol Pract. 2017 Apr;13(4):265-269
pubmed: 28399382
Strahlenther Onkol. 2016 Dec;192(12):886-894
pubmed: 27757502
Int J Radiat Oncol Biol Phys. 2012 Feb 1;82(2):809-16
pubmed: 21277694
Arch Surg. 1985 Aug;120(8):899-903
pubmed: 4015380
Am J Surg. 2008 Mar;195(3):318-21
pubmed: 18308038
Pract Radiat Oncol. 2018 Mar - Apr;8(2):107-115
pubmed: 29426692
Radiat Oncol. 2013 Jun 21;8:148
pubmed: 23799996
BMC Cancer. 2017 Jul 27;17(1):505
pubmed: 28750659
JAMA Oncol. 2019 Jul 1;5(7):1020-1027
pubmed: 31145418
Curr Oncol. 2019 Oct;26(5):e665-e681
pubmed: 31708660
Anticancer Res. 2020 Jan;40(1):465-472
pubmed: 31892602
Lancet. 2017 Mar 11;389(10073):1011-1024
pubmed: 28129987
Pract Radiat Oncol. 2020 Feb 13;:
pubmed: 32061993
Int J Radiat Oncol Biol Phys. 2016 Mar 15;94(4):755-65
pubmed: 26972648
Radiother Oncol. 2018 Nov;129(2):319-325
pubmed: 30174107
Cancer. 2015 Apr 1;121(7):1128-37
pubmed: 25538019
Cancer. 2013 Aug 1;119(15):2692-700
pubmed: 23720019
J Gastrointest Cancer. 2019 Mar;50(1):1-8
pubmed: 30446922
Ann Surg Oncol. 2006 Sep;13(9):1201-8
pubmed: 16955382
J Clin Oncol. 2020 Jun 1;38(16):1763-1773
pubmed: 32105518
Radiother Oncol. 2020 Feb;143:101-107
pubmed: 32044168
J Gastrointest Surg. 2006 Nov;10(9):1199-210; discussion 1210-1
pubmed: 17114007
CA Cancer J Clin. 2019 Jan;69(1):7-34
pubmed: 30620402
J Appl Clin Med Phys. 2019 Jun;20(6):194-198
pubmed: 31055870
J Clin Oncol. 2005 Jul 10;23(20):4538-44
pubmed: 16002845
J Am Coll Surg. 2008 May;206(5):833-46; discussion 846-8
pubmed: 18471707
N Engl J Med. 2004 Mar 18;350(12):1200-10
pubmed: 15028824
Oncotarget. 2018 Mar 27;9(23):16427-16436
pubmed: 29662656
BMC Cancer. 2019 Jun 11;19(1):569
pubmed: 31185957
Clin Transl Oncol. 2020 Sep;22(9):1499-1505
pubmed: 31974820
Cureus. 2018 Mar 9;10(3):e2292
pubmed: 29750133
JAMA. 2016 May 3;315(17):1844-53
pubmed: 27139057
J Clin Oncol. 2011 Nov 1;29(31):4105-12
pubmed: 21969502
J Surg Oncol. 2010 Jun 1;101(7):587-92
pubmed: 20461765
JAMA Oncol. 2018 Jul 1;4(7):963-969
pubmed: 29800971
Pancreatology. 2018 Dec;18(8):962-970
pubmed: 30292643
Int J Radiat Oncol Biol Phys. 2013 Jul 1;86(3):516-22
pubmed: 23562768
Cancer Res. 2014 Jun 1;74(11):2913-21
pubmed: 24840647
Crit Rev Oncol Hematol. 2017 Mar;111:152-165
pubmed: 28259290
Ann Surg Oncol. 2010 Apr;17(4):981-90
pubmed: 20087786
Int J Radiat Oncol Biol Phys. 2013 Dec 1;87(5):1000-6
pubmed: 24267968
Ann Surg. 1999 Dec;230(6):776-82; discussion 782-4
pubmed: 10615932
Strahlenther Onkol. 2015 Jan;191(1):7-16
pubmed: 25252602
Pancreas. 2004 Jan;28(1):e26-31
pubmed: 14707745
ESMO Open. 2018 Jan 27;3(1):e000282
pubmed: 29387477
Dig Liver Dis. 2017 Feb;49(2):223-226
pubmed: 27931968
Radiat Oncol. 2019 Apr 29;14(1):71
pubmed: 31036034
Acta Oncol. 2011 Aug;50(6):763-71
pubmed: 21767172
Cancer. 2013 Jan 1;119(1):45-51
pubmed: 22744973
Ann Surg Oncol. 2015 Jul;22(7):2352-8
pubmed: 25564157
Ann Oncol. 2015 Sep;26 Suppl 5:v56-68
pubmed: 26314780
Front Oncol. 2016 Jun 07;6:140
pubmed: 27376030
J Gastrointest Surg. 2015 Oct;19(10):1802-12
pubmed: 26224039
Clin Transl Oncol. 2017 Jun;19(6):667-681
pubmed: 27995549
Ann Surg Oncol. 2009 Apr;16(4):836-47
pubmed: 19194760
Int J Radiat Oncol Biol Phys. 2014 Jul 15;89(4):830-8
pubmed: 24867540
Pract Radiat Oncol. 2020 May - Jun;10(3):e136-e146
pubmed: 31761541
J Gastrointest Surg. 2012 Mar;16(3):509-17
pubmed: 22183861
Int J Radiat Oncol Biol Phys. 2008 Nov 1;72(3):678-86
pubmed: 18395362
J Surg Res. 2012 May 15;174(2):319-25
pubmed: 21937061
Semin Radiat Oncol. 2014 Apr;24(2):105-12
pubmed: 24635867
Br J Surg. 2018 Jul;105(8):946-958
pubmed: 29708592
Radiother Oncol. 2019 Jul;136:37-43
pubmed: 31015127
J Palliat Care. 2003 Winter;19(4):258-62
pubmed: 14959596
Int J Radiat Oncol Biol Phys. 2011 Sep 1;81(1):181-8
pubmed: 21549517
Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):e615-22
pubmed: 21658854
Surg Oncol Clin N Am. 2017 Jul;26(3):431-453
pubmed: 28576181
Am J Clin Oncol. 2011 Feb;34(1):63-9
pubmed: 20308870
Expert Opin Pharmacother. 2014 Jan;15(1):143-50
pubmed: 24283747
Ann Surg Oncol. 2009 Jul;16(7):1727-33
pubmed: 19396496
Acta Oncol. 2015 Jul;54(7):979-85
pubmed: 25734581
Lancet Oncol. 2013 Apr;14(4):317-26
pubmed: 23474363
Cancer Res. 2018 Aug 1;78(15):4282-4291
pubmed: 29844122
Int J Radiat Oncol Biol Phys. 2005 Jul 15;62(4):1021-9
pubmed: 15990004
J Am Coll Surg. 2008 Oct;207(4):510-9
pubmed: 18926452
Langenbecks Arch Surg. 2012 Aug;397(6):927-32
pubmed: 22382704
Am J Clin Oncol. 2019 Oct;42(10):755-760
pubmed: 31513018
Radiat Oncol. 2013 Mar 01;8:44
pubmed: 23452509
N Engl J Med. 2006 Jul 6;355(1):11-20
pubmed: 16822992
Curr Opin Immunol. 2013 Apr;25(2):200-5
pubmed: 23422836
Cancer Res. 2007 Oct 1;67(19):9518-27
pubmed: 17909062
Clin Transl Radiat Oncol. 2019 Apr 25;18:128-130
pubmed: 31341988
Cancers (Basel). 2019 Jul 12;11(7):
pubmed: 31336859
Nat Rev Cancer. 2015 Jul;15(7):409-25
pubmed: 26105538
Radiat Oncol. 2010 Apr 15;5:28
pubmed: 20398316
Lancet Oncol. 2011 Jun;12(6):575-82
pubmed: 21596621
Int J Radiat Oncol Biol Phys. 2004 Mar 15;58(4):1017-21
pubmed: 15001240
N Engl J Med. 2010 Apr 29;362(17):1605-17
pubmed: 20427809
N Engl J Med. 2018 Dec 20;379(25):2395-2406
pubmed: 30575490
JAMA. 2008 Mar 5;299(9):1019-26
pubmed: 18319412
Dtsch Arztebl Int. 2014 May 30;111(22):396-402
pubmed: 24980565
J Clin Oncol. 2019 Aug 10;37(23):2082-2088
pubmed: 31180816
Am J Clin Oncol. 2008 Oct;31(5):446-53
pubmed: 18838880
Lancet Oncol. 2015 Sep;16(9):1090-1098
pubmed: 26254683
Crit Rev Oncol Hematol. 2016 Feb;98:309-24
pubmed: 26653573
J Radiat Res. 2016 Aug;57 Suppl 1:i53-i57
pubmed: 27029741
Pract Radiat Oncol. 2017 Mar - Apr;7(2):126-136
pubmed: 28089481
Radiat Oncol. 2010 Jul 08;5:64
pubmed: 20615227
HPB (Oxford). 2013 Sep;15(9):716-23
pubmed: 23458326
Int J Radiat Oncol Biol Phys. 2012 Jul 1;83(3):901-8
pubmed: 22483737
J Am Coll Surg. 2012 Jul;215(1):41-51; discussion 51-2
pubmed: 22608401
Am J Clin Oncol. 2019 Mar;42(3):247-252
pubmed: 30724781
Radiother Oncol. 2019 May;134:110-118
pubmed: 31005204
Radiother Oncol. 2017 Dec;125(3):439-444
pubmed: 28811038
Semin Radiat Oncol. 2013 Oct;23(4):273-80
pubmed: 24012341
J Clin Oncol. 2012 Jun 1;30(16):1926-33
pubmed: 22529255
Pract Radiat Oncol. 2019 Jan;9(1):e46-e54
pubmed: 30149192
Int J Radiat Oncol Biol Phys. 2017 Feb 1;97(2):313-322
pubmed: 28068239
Semin Diagn Pathol. 2014 Nov;31(6):443-451
pubmed: 25441308
Int J Radiat Oncol Biol Phys. 2018 Aug 1;101(5):1212-1221
pubmed: 29907490
Ann Surg Oncol. 2010 Aug;17(8):2092-101
pubmed: 20224860
Surgery. 2012 Sep;152(3 Suppl 1):S33-42
pubmed: 22770956
JAMA. 2007 Jan 17;297(3):267-77
pubmed: 17227978
Can Urol Assoc J. 2015 Jul-Aug;9(7-8):275-80
pubmed: 26316914
Pancreas. 2017 May/Jun;46(5):595-604
pubmed: 28426492
Lancet Oncol. 2015 Oct;16(13):e498-509
pubmed: 26433823
Ann Surg. 2018 Aug;268(2):215-222
pubmed: 29462005
J Surg Oncol. 2013 Sep;108(4):236-41
pubmed: 23955427
Rays. 2003 Jul-Sep;28(3):311-5
pubmed: 15018319
J Surg Oncol. 2018 Apr;117(5):1073-1083
pubmed: 29448308