Differences in Gene Expression Profile of Primary Tumors in Metastatic and Non-Metastatic Papillary Thyroid Carcinoma-Do They Exist?
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ genetics
Carcinoma, Papillary
/ genetics
Child
Child, Preschool
Extracellular Matrix Proteins
/ genetics
Female
Gene Expression
Gene Expression Profiling
Humans
Male
Middle Aged
Neoplasm Metastasis
Thyroid Cancer, Papillary
/ genetics
Thyroid Neoplasms
/ genetics
Transcriptome
distant metastases
gene expression profile
microarray
papillary thyroid cancer
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Jun 2020
29 Jun 2020
Historique:
received:
17
05
2020
revised:
22
06
2020
accepted:
26
06
2020
entrez:
3
7
2020
pubmed:
3
7
2020
medline:
20
2
2021
Statut:
epublish
Résumé
Molecular mechanisms of distant metastases (M1) in papillary thyroid cancer (PTC) are poorly understood. We attempted to analyze the gene expression profile in PTC primary tumors to seek the genes associated with M1 status and characterize their molecular function. One hundred and twenty-three patients, including 36 M1 cases, were subjected to transcriptome oligonucleotide microarray analyses: (set A-U133, set B-HG 1.0 ST) at transcript and gene group level (limma, gene set enrichment analysis (GSEA)). An additional independent set of 63 PTCs, including 9 M1 cases, was used to validate results by qPCR. The analysis on dataset A detected eleven transcripts showing significant differences in expression between metastatic and non-metastatic PTC. These genes were validated on microarray dataset B. The differential expression was positively confirmed for only two genes:
Identifiants
pubmed: 32610693
pii: ijms21134629
doi: 10.3390/ijms21134629
pmc: PMC7369779
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Extracellular Matrix Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Polish National Center of Research and Development MILESTONE project - Molecular diagnostics and imaging in individualized therapy for breast, thyroid and prostate cancer
ID : STRATEGMED 2/267398/4/NCBR/2015
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