Cross-sectional Study on Vitamin D Status in CKD Patients.

BACKGROUND

Chronic Kidney Disease (CKD) is defined as a disease characterized by alterations in either kidney structure or function or both for a minimum of 3 months duration. New evidences have established new paradigm in the management of CKD patients having Vitamin D deficiency. It appears in some studies that adequate replacement of Vitamin D in deficient population can reduce premature mortality and morbidity in CKD population.

AIMS AND OBJECTIVES

This cross-sectional study is designed "To assess Vitamin D status in CKD patients and to correlate Vitamin D status with eGFR.

METHODOLOGY

A retrospective cross sectional study on 100 cases of Chronic Kidney Disease patients and matched control subjects in a tertiary care hospital of Eastern India. eGFR was calculated using MDRD-EPI study equation. Vitamin D status was measured using 25(OH) vitamin D levels. Correlation was calculated by Pearson correlation analysis.

RESULTS

Among 100 cases, 56 were male and 44 were female. Among 100 control, 53 were female and 47 were male. Among the cases, the mean eGFR was 25.15 ± 11.89. Among the control, the mean eGFR was 87.22 ± 17.82. Among the cases, the mean Vitamin D (Vit D) was 22.57 ± 9.76. Among the control, the mean Vit D was 35.24 ± 10.18. Among the cases, in non-dialysis patients the mean Vit D was 25.66 ± 8.54 and in dialysis patients the mean Vit D was 10.94 ± 2.65. Among the cases, 38 patients had Vit D deficiency (<20), 44 patients had Vit D insufficiency (20-30) and 18 patients had normal Vit D (>30). The positive correlation was found between eGFR and vitamin D level and that was statistically significant.

CONCLUSION

Both deficiency and insufficiency of Vitamin D were higher in CKD patients compared to control. Vitamin-D deficiency was more pronounced in advanced stages of CKD. eGFR was strongly associated with serum vitamin-D level.

Informations de copyright

© Journal of the Association of Physicians of India 2011.