Rapid and Systematic Exploration of Chemical Space Relevant to Artemisinins: Anti-malarial Activities of Skeletally Diversified Tetracyclic Peroxides and 6-Aza-artemisinins.

Antimalarials / pharmacology Artemisinins / pharmacology Peroxides / pharmacology

Journal

The Journal of organic chemistry
ISSN: 1520-6904
Titre abrégé: J Org Chem
Pays: United States
ID NLM: 2985193R

Informations de publication

Date de publication:
07 08 2020
Historique:
pubmed: 3 7 2020
medline: 24 6 2021
entrez: 3 7 2020
Statut: ppublish

Résumé

To achieve both structural changes and rapid synthesis of the tetracyclic scaffold relevant to artemisinins, we explored two kinds of

Identifiants

DOI: 10.1021/acs.joc.0c01017 PMID: 32610901
pubmed: 32610901
doi: 10.1021/acs.joc.0c01017
doi:

Substances chimiques

Antimalarials 0
Artemisinins 0
Peroxides 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9694-9712

Auteurs

Karunakar Reddy Bonepally (KR)

Division of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo 184-8588, Japan.

Norihito Takahashi (N)

Division of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo 184-8588, Japan.

Naoya Matsuoka (N)

Division of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo 184-8588, Japan.

Hikari Koi (H)

Division of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo 184-8588, Japan.

Haruki Mizoguchi (H)

Division of Chemistry, Graduate School of Science, Hokkaido University, North 10 West 8, Kitaku, Sapporo 060-0810, Japan.
ORCID: 0000-0002-2148-9699

Takahisa Hiruma (T)

Division of Chemistry, Graduate School of Science, Hokkaido University, North 10 West 8, Kitaku, Sapporo 060-0810, Japan.

Kyohei Ochiai (K)

Division of Chemistry, Graduate School of Science, Hokkaido University, North 10 West 8, Kitaku, Sapporo 060-0810, Japan.

Shun Suzuki (S)

Division of Chemistry, Graduate School of Science, Hokkaido University, North 10 West 8, Kitaku, Sapporo 060-0810, Japan.

Yutaka Yamagishi (Y)

Division of Chemistry, Graduate School of Science, Hokkaido University, North 10 West 8, Kitaku, Sapporo 060-0810, Japan.

Hideaki Oikawa (H)

Division of Chemistry, Graduate School of Science, Hokkaido University, North 10 West 8, Kitaku, Sapporo 060-0810, Japan.
ORCID: 0000-0002-6947-3397

Aki Ishiyama (A)

Research Center for Tropical Diseases, O̅mura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

Rei Hokari (R)

Research Center for Tropical Diseases, O̅mura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

Masato Iwatsuki (M)

Research Center for Tropical Diseases, O̅mura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

Kazuhiko Otoguro (K)

Research Center for Tropical Diseases, O̅mura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

Satoshi O Mura (S)

Research Center for Tropical Diseases, O̅mura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

Nobutaka Kato (N)

Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, United States.

Hiroki Oguri (H)

Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
ORCID: 0000-0001-8007-1631

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Antipaludiques › Rapid and Systematic Exploration of Chemical...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesquiterpènes › Artémisinines › Rapid and Systematic Exploration of Chemical...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Rapid and Systematic Exploration of Chemical...