Identification of a Potent Oridonin Analogue for Treatment of Triple-Negative Breast Cancer.

Animals Cell Line, Tumor Diterpenes, Kaurane / chemistry Humans Male Mice Mice, Inbred ICR Mice, Nude Triple Negative Breast Neoplasms / drug therapy Xenograft Model Antitumor Assays / methods

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
13 08 2020
Historique:
pubmed: 3 7 2020
medline: 26 11 2020
entrez: 3 7 2020
Statut: ppublish

Résumé

Triple-negative breast cancer (TNBC) is one of the most highly invasive and metastatic breast cancers without safe and effective therapeutic drugs. The natural product oridonin is reported to be a potential anti-TNBC agent. However, its moderate activity and complex structure hampered its clinical application. In this study, the novel oridonin analogues were first identified by removal of multiple hydroxyl groups and structural simplification of oridonin. The representative analogue

Identifiants

DOI: 10.1021/acs.jmedchem.0c00408 PMID: 32610904
pubmed: 32610904
doi: 10.1021/acs.jmedchem.0c00408
doi:

Substances chimiques

Diterpenes, Kaurane 0
oridonin 0APJ98UCLQ

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

8157-8178

Auteurs

Hong Yao (H)

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.

Shaowen Xie (S)

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.

Xiaoqian Ma (X)

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.

Junkai Liu (J)

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.

Hongyu Wu (H)

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.

Aijun Lin (A)

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
ORCID: 0000-0001-5786-4537

Hequan Yao (H)

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.

Dahong Li (D)

Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
ORCID: 0000-0002-6964-4619

Shengtao Xu (S)

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
ORCID: 0000-0002-5705-6377

Dong-Hua Yang (DH)

College of Pharmacy and Health Sciences, St. John's University, 8000 Utopia Parkway, Queens, New York 11439, United States.

Zhe-Sheng Chen (ZS)

College of Pharmacy and Health Sciences, St. John's University, 8000 Utopia Parkway, Queens, New York 11439, United States.
ORCID: 0000-0002-8289-097X

Jinyi Xu (J)

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China.
ORCID: 0000-0002-1961-0402

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Identification of a Potent Oridonin Analogue...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Identification of a Potent Oridonin Analogue...
questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Alcaloïdes diterpéniques › Diterpènes de type kaurane › Identification of a Potent Oridonin Analogue...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification of a Potent Oridonin Analogue...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Identification of a Potent Oridonin Analogue...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée ICR › Identification of a Potent Oridonin Analogue...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris nude › Identification of a Potent Oridonin Analogue...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Tumeurs du sein triple-négatives › Identification of a Potent Oridonin Analogue...
questionsmedicales.fr › Techniques d'investigation › Transplantation tumorale › Tests d'activité antitumorale sur modèle de xénogreffe › Identification of a Potent Oridonin Analogue...