Ykt6-dependent endosomal recycling is required for Wnt secretion in the

Animals Drosophila Proteins / genetics Drosophila melanogaster Endosomes / genetics Epithelium / embryology R-SNARE Proteins / genetics Wings, Animal / embryology Wnt Proteins / genetics
Endosomal sorting Morphogen trafficking Wnt secretion Wnt signalling

Journal

Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744

Informations de publication

Date de publication:
14 08 2020
Historique:
received: 09 10 2019
accepted: 08 06 2020
pubmed: 3 7 2020
medline: 24 3 2021
entrez: 3 7 2020
Statut: epublish

Résumé

Morphogens are important signalling molecules for tissue development and their secretion requires tight regulation. In the wing imaginal disc of flies, the morphogen Wnt/Wingless is apically presented by the secreting cell and re-internalized before final long-range secretion. Why Wnt molecules undergo these trafficking steps and the nature of the regulatory control within the endosomal compartment remain unclear. Here, we have investigated how Wnts are sorted at the level of endosomes by the versatile v-SNARE Ykt6. Using

Identifiants

DOI: 10.1242/dev.185421 PMID: 32611603 PMC: PMC7438013
pubmed: 32611603
pii: dev.185421
doi: 10.1242/dev.185421
pmc: PMC7438013
pii:
doi:

Substances chimiques

Drosophila Proteins 0
R-SNARE Proteins 0
Wnt Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2020. Published by The Company of Biologists Ltd.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare no competing or financial interests.

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Auteurs

Karen Linnemannstöns (K)

Hematology and Oncology, University Medical Centre Goettingen, Goettingen 37075, Germany.
Developmental Biochemistry, University Medical Centre Goettingen, Goettingen 37077, Germany.

Leonie Witte (L)

Hematology and Oncology, University Medical Centre Goettingen, Goettingen 37075, Germany.
Developmental Biochemistry, University Medical Centre Goettingen, Goettingen 37077, Germany.

Pradhipa Karuna M (P)

Hematology and Oncology, University Medical Centre Goettingen, Goettingen 37075, Germany.
Developmental Biochemistry, University Medical Centre Goettingen, Goettingen 37077, Germany.

Jeanette Clarissa Kittel (JC)

Hematology and Oncology, University Medical Centre Goettingen, Goettingen 37075, Germany.
Developmental Biochemistry, University Medical Centre Goettingen, Goettingen 37077, Germany.

Adi Danieli (A)

Hematology and Oncology, University Medical Centre Goettingen, Goettingen 37075, Germany.
Developmental Biochemistry, University Medical Centre Goettingen, Goettingen 37077, Germany.

Denise Müller (D)

Hematology and Oncology, University Medical Centre Goettingen, Goettingen 37075, Germany.
Developmental Biochemistry, University Medical Centre Goettingen, Goettingen 37077, Germany.

Lena Nitsch (L)

Hematology and Oncology, University Medical Centre Goettingen, Goettingen 37075, Germany.
Developmental Biochemistry, University Medical Centre Goettingen, Goettingen 37077, Germany.

Mona Honemann-Capito (M)

Hematology and Oncology, University Medical Centre Goettingen, Goettingen 37075, Germany.
Developmental Biochemistry, University Medical Centre Goettingen, Goettingen 37077, Germany.

Ferdinand Grawe (F)

Molecular Cell Biology, Institute I for Anatomy, University of Cologne Medical School, Cologne 50931, Germany.
Cluster of Excellence-Cellular Stress Response in Aging-Associated Diseases (CECAD), Cologne 50931, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, 50931 Cologne, Germany.

Andreas Wodarz (A)

Molecular Cell Biology, Institute I for Anatomy, University of Cologne Medical School, Cologne 50931, Germany.
Cluster of Excellence-Cellular Stress Response in Aging-Associated Diseases (CECAD), Cologne 50931, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Faculty of Medicine and University Hospital Cologne, 50931 Cologne, Germany.

Julia Christina Gross (JC)

Hematology and Oncology, University Medical Centre Goettingen, Goettingen 37075, Germany julia.gross@med.uni-goettingen.de.
Developmental Biochemistry, University Medical Centre Goettingen, Goettingen 37077, Germany.
ORCID: 0000-0002-8939-5664

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Ykt6-dependent endosomal recycling is required...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › Protéines de Drosophila › Ykt6-dependent endosomal recycling is required...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › Ykt6-dependent endosomal recycling is required...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Endosomes › Ykt6-dependent endosomal recycling is required...
questionsmedicales.fr › Tissus › Épithélium › Ykt6-dependent endosomal recycling is required...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Protéines SNARE › Protéines R-SNARE › Ykt6-dependent endosomal recycling is required...
questionsmedicales.fr › Structures anatomiques de l'animal › Membre thoracique › Ailes d'animaux › Ykt6-dependent endosomal recycling is required...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de type Wingless › Ykt6-dependent endosomal recycling is required...