Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium.
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
04 08 2020
04 08 2020
Historique:
received:
11
07
2019
accepted:
31
01
2020
pubmed:
3
7
2020
medline:
10
10
2020
entrez:
3
7
2020
Statut:
ppublish
Résumé
To determine changes in the incidence of dementia between 1988 and 2015. This analysis was performed in aggregated data from individuals >65 years of age in 7 population-based cohort studies in the United States and Europe from the Alzheimer Cohort Consortium. First, we calculated age- and sex-specific incidence rates for all-cause dementia, and then defined nonoverlapping 5-year epochs within each study to determine trends in incidence. Estimates of change per 10-year interval were pooled and results are presented combined and stratified by sex. Of 49,202 individuals, 4,253 (8.6%) developed dementia. The incidence rate of dementia increased with age, similarly for women and men, ranging from about 4 per 1,000 person-years in individuals aged 65-69 years to 65 per 1,000 person-years for those aged 85-89 years. The incidence rate of dementia declined by 13% per calendar decade (95% confidence interval [CI], 7%-19%), consistently across studies, and somewhat more pronouncedly in men than in women (24% [95% CI 14%-32%] vs 8% [0%-15%]). The incidence rate of dementia in Europe and North America has declined by 13% per decade over the past 25 years, consistently across studies. Incidence is similar for men and women, although declines were somewhat more profound in men. These observations call for sustained efforts to finding the causes for this decline, as well as determining their validity in geographically and ethnically diverse populations.
Identifiants
pubmed: 32611641
pii: WNL.0000000000010022
doi: 10.1212/WNL.0000000000010022
pmc: PMC7455342
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e519-e531Subventions
Organisme : NINDS NIH HHS
ID : UH3 NS100605
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS017950
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054076
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG059421
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500001C
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL130114
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062421
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : Medical Research Council
ID : G9901400
Pays : United Kingdom
Organisme : Medical Research Council
ID : G06010220
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : N01AG12100
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG008122
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG033193
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500001I
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC25195
Pays : United States
Organisme : NINDS NIH HHS
ID : UH2 NS100605
Pays : United States
Organisme : Medical Research Council
ID : MR/R015600/1
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : HHSN271201200022C
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG049505
Pays : United States
Organisme : Medical Research Council
ID : G0601022
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG049607
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066546
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG033040
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG052409
Pays : United States
Informations de copyright
Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
Références
Acta Psychiatr Scand. 2007 Jan;115(1):73-9
pubmed: 17201869
Clin Epidemiol. 2018 Sep 18;10:1233-1247
pubmed: 30271219
Prev Med. 1975 Dec;4(4):518-25
pubmed: 1208363
Lancet. 2017 Sep 16;390(10100):1211-1259
pubmed: 28919117
Neurology. 2017 May 16;88(20):1925-1932
pubmed: 28424272
Eur J Epidemiol. 2017 Oct;32(10):931-938
pubmed: 29063414
J Hypertens. 2017 Jul;35(7):1424-1431
pubmed: 28403041
Alzheimers Dement. 2016 Mar;12(3):244-51
pubmed: 26218444
Neuroepidemiology. 2003 Nov-Dec;22(6):316-25
pubmed: 14598854
Eur J Epidemiol. 2015 Aug;30(8):661-708
pubmed: 26386597
Acta Med Scand. 1973 Apr;193(4):311-8
pubmed: 4717311
Lancet. 2015 Aug 22;386(9995):743-800
pubmed: 26063472
J Alzheimers Dis. 2017 Oct 3;60(3):1065-1075
pubmed: 28984588
Brain. 2010 Aug;133(Pt 8):2210-6
pubmed: 20826429
N Engl J Med. 2013 Dec 12;369(24):2275-7
pubmed: 24283198
Alzheimers Dement. 2016 Mar;12(3):272-80
pubmed: 26693893
Lancet. 2016 Apr 2;387(10026):1377-1396
pubmed: 27115820
N Engl J Med. 1980 Jul 17;303(3):130-5
pubmed: 7383070
Am J Epidemiol. 2007 May 1;165(9):1076-87
pubmed: 17351290
Lancet. 2013 Oct 26;382(9902):1405-12
pubmed: 23871492
Am J Public Health. 2013 Jul;103(7):1207-18
pubmed: 23678895
Am J Public Health Nations Health. 1951 Mar;41(3):279-81
pubmed: 14819398
Lancet. 2017 Jan 7;389(10064):37-55
pubmed: 27863813
Alzheimers Dement (Amst). 2018 Aug 09;10:490-497
pubmed: 30310851
N Engl J Med. 2016 Feb 11;374(6):523-32
pubmed: 26863354
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Rev Neurol (Paris). 1991;147(3):225-30
pubmed: 2063070
Alzheimers Dement. 2019 Jan;15(1):1-7
pubmed: 30195482
Neurology. 2012 May 8;78(19):1456-63
pubmed: 22551732
Nat Commun. 2016 Apr 19;7:11398
pubmed: 27092707