White matter atrophy in cerebral amyloid angiopathy.
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
04 08 2020
04 08 2020
Historique:
received:
20
11
2018
accepted:
10
01
2020
pubmed:
3
7
2020
medline:
10
10
2020
entrez:
3
7
2020
Statut:
ppublish
Résumé
We postulated that cerebral amyloid angiopathy (CAA) is associated with white matter atrophy (WMA) and that WMA can be related to cognitive changes in CAA. White matter volume expressed as percent of intracranial volume (pWMV) of prospectively enrolled patients without dementia diagnosed with probable CAA was compared to age-matched healthy controls (HC) and patients with Alzheimer disease (AD). Cognitive scores were also sought to understand the potential effects of WMA on cognitive function. Patients with CAA (n = 72) had significantly lower pWMV (27.97% ± 2.63) when compared to age-matched HC (n = 72; mean difference [MD], 2.38%; Patients with CAA show WMA when compared to age-matched HC and patients with AD. WMA independently correlates with the number of lobar microbleeds, a marker of CAA severity. Consistent spatial patterns of WMA especially in posterior regions might be related to CAA. The association between WMA and measures of executive function suggests that WMA might represent an important mediator of CAA-related neurologic dysfunction.
Identifiants
pubmed: 32611644
pii: WNL.0000000000010017
doi: 10.1212/WNL.0000000000010017
pmc: PMC7455340
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e554-e562Subventions
Organisme : NIA NIH HHS
ID : P30 AG062715
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS114526
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066462
Pays : United States
Organisme : CIHR
Pays : Canada
Investigateurs
Michael W. Weiner
(MW)
Paul Aisen
(P)
Ronald Petersen
(R)
Clifford R. Jack
(CR)
William Jagust
(W)
John Q. Trojanowki
(JQ)
Laurel Beckett
(L)
Robert C. Green
(RC)
Andrew J. Saykin
(AJ)
John Morris
(J)
Zaven Khachaturian
(Z)
Greg Sorensen
(G)
Maria Carrillo
(M)
Lew Kuller
(L)
Marc Raichle
(M)
Steven Paul
(S)
Peter Davies
(P)
Howard Fillit
(H)
Franz Hefti
(F)
David Holtzman
(D)
M. Marcel Mesulam
(MM)
William Potter
(W)
Peter Snyder
(P)
Tom Montine
(T)
Ronald Petersen
(R)
Gustavo Jimenez
(G)
Michael Donohue
(M)
Devon Gessert
(D)
Kelly Harless
(K)
Jennifer Salazar
(J)
Yuliana Cabrera
(Y)
Sarah Walter
(S)
Lindsey Hergesheimer
(L)
Laurel Beckett
(L)
Matthew Bernstein
(M)
Nick Fox
(N)
Paul Thompson
(P)
Norbert Schuff
(N)
Charles DeCArli
(C)
Bret Borowski
(B)
Jeff Gunter
(J)
Matt Senjem
(M)
Prashanthi Vemuri
(P)
David Jones
(D)
Kejal Kantarci
(K)
Chad Ward
(C)
Robert A. Koeppe
(RA)
Norm Foster
(N)
Eric M. Reiman
(EM)
Kewei Chen
(K)
Chet Mathis
(C)
John C. Morris
(JC)
Nigel J. Cairns
(NJ)
Erin Franklin
(E)
Lisa Taylor-Reinwald
(L)
Leslie M. Shaw
(LM)
Virginia Lee
(V)
Magdalena Korecka
(M)
Michal Figurski
(M)
Arthur W. Toga
(AW)
Karen Crawford
(K)
Scott Neu
(S)
Tatiana M. Foroud
(TM)
Steven Potkin
(S)
Li Shen
(L)
Kelley Faber
(K)
Sungeun Kim
(S)
Kwangsik Nho
(K)
Lean Thal
(L)
Zaven Khachaturian
(Z)
Leon Thal
(L)
Neil Buckholtz
(N)
Peter J. Snyder
(PJ)
William Potter
(W)
Steven Paul
(S)
Marilyn Albert
(M)
Richard Frank
(R)
Zaven Khachaturian
(Z)
John Hsiao
(J)
Joseph Quinn
(J)
Lisa C. Silbert
(LC)
Betty Lind
(B)
Jeffrey A. Kaye
(JA)
Raina Carter
(R)
Sara Dolen
(S)
Lon S. Schneider
(LS)
Sonia Pawluczyk
(S)
Mauricio Becerra
(M)
Liberty Teodoro
(L)
Bryan M. Spann
(BM)
James Brewer
(J)
Helen Vanderswag
(H)
Adam Fleisher
(A)
Jaimie Ziolkowski
(J)
Judith L. Heidebrink
(JL)
Joanne L. Lord
(JL)
Ronald Petersen
(R)
Sara S. Mason
(SS)
Colleen S. Albers
(CS)
David Knopman
(D)
Kris Johnson
(K)
Javier Villanueva-Meyer
(J)
Valory Pavlik
(V)
Nathaniel Pacini
(N)
Ashley Lamb
(A)
Joseph S. Kass
(JS)
Rachelle S. Doody
(RS)
Victoria Shibley
(V)
Munir Chowdhury
(M)
Susan Rountree
(S)
Mimi Dang
(M)
Yaakov Stern
(Y)
Lawrence S. Honig
(LS)
Karen L. Bell
(KL)
Randy Yeh
(R)
Beau Ances
(B)
David Winkfield
(D)
Maria Carroll
(M)
Angela Oliver
(A)
Mary L. Creech
(ML)
Mark A. Mintun
(MA)
Stacy Schneider
(S)
Daniel Marson
(D)
David Geldmacher
(D)
Marissa Natelson Love
(M)
Randall Griffith
(R)
David Clark
(D)
John Brockington
(J)
Hillel Grossman
(H)
Effie Mitsis
(E)
Raj C. Shah
(RC)
Melissa Lamar
(M)
Patricia Samuels
(P)
Ranjan Duara
(R)
Maria T. Greig-Custo
(MT)
Rosemarie Rodriguez
(R)
Marilyn Albert
(M)
Chiadi Onyike
(C)
Daniel D’Agostino
(D)
Stephanie Kielb
(S)
Martin Sadowski
(M)
Mohammed O. Sheikh
(MO)
Jamika Singleton-Garvin
(J)
Anaztasia Ulysse
(A)
Mrunalini Gaikwad
(M)
P Murali Doraiswamy
(P)
Jeffrey R. Petrella
(JR)
Olga James
(O)
Salvador Borges-Neto
(S)
Terence Z. Wong
(TZ)
Edward Coleman
(E)
Jason H. Karlawish
(JH)
David A. Wolk
(DA)
Sanjeev Vaishnavi
(S)
Christopher M. Clark
(CM)
Steven E. Arnold
(SE)
Charles D. Smith
(CD)
Greg Jicha
(G)
Peter Hardy
(P)
Riham El Khouli
(R)
Elizabeth Oates
(E)
Gary Conrad
(G)
Oscar L. Lopez
(OL)
MaryAnn Oakley
(M)
Donna M. Simpson
(DM)
Anton P. Porsteinsson
(AP)
Kim Martin
(K)
Nancy Kowalksi
(N)
Melanie Keltz
(M)
Bonnie S. Goldstein
(BS)
Kelly M. Makino
(KM)
M. Saleem Ismail
(MS)
Connie Brand
(C)
Gaby Thai
(G)
Aimee Pierce
(A)
Beatriz Yanez
(B)
Elizabeth Sosa
(E)
Megan Witbracht
(M)
Kyle Womack
(K)
Dana Mathews
(D)
Mary Quiceno
(M)
Allan I. Levey
(AI)
James J. Lah
(JJ)
Janet S. Cellar
(JS)
Jeffrey M. Burns
(JM)
Russell H. Swerdlow
(RH)
William M. Brooks
(WM)
Ellen Woo
(E)
Daniel H.S. Silverman
(DH)
Edmond Teng
(E)
Sarah Kremen
(S)
Liana Apostolova
(L)
Kathleen Tingus
(K)
Po H. Lu
(PH)
George Bartzokis
(G)
Neill R Graff-Radford
(NR)
Francine Parfitt
(F)
Kim Poki-Walker
(K)
Martin R. Farlow
(MR)
Ann Marie Hake
(AM)
Brandy R. Matthews
(BR)
Jared R. Brosch
(JR)
Scott Herring
(S)
Christopher H. van Dyck
(CH)
Richard E. Carson
(RE)
Pradeep Varma
(P)
Howard Chertkow
(H)
Howard Bergman
(H)
Chris Hosein
(C)
Sandra Black
(S)
Bojana Stefanovic
(B)
Chris (Chinthaka) Heyn
(C)
Ging-Yuek Robin Hsiung
(GR)
Benita Mudge
(B)
Vesna Sossi
(V)
Howard Feldman
(H)
Michele Assaly
(M)
Elizabeth Finger
(E)
Stephen Pasternack
(S)
William Pavlosky
(W)
Irina Rachinsky
(I)
Dick Drost
(D)
Andrew Kertesz
(A)
Charles Bernick
(C)
Donna Munic
(D)
Emily Rogalski
(E)
Marek-Marsel Mesulam
(MM)
Kristine Lipowski
(K)
Sandra Weintraub
(S)
Borna Bonakdarpour
(B)
Diana Kerwin
(D)
Chuang-Kuo Wu
(CK)
Nancy Johnson
(N)
Carl Sadowsky
(C)
Teresa Villena
(T)
Raymond Scott Turner
(R)
Kathleen Johnson
(K)
Brigid Reynolds
(B)
Reisa A. Sperling
(RA)
Keith A. Johnson
(KA)
None Gad A. Marshall
None Jerome Yesavage
Joy L. Taylor
(JL)
Steven Chao
(S)
Barton Lane
(B)
Allyson Rosen
(A)
Jared Tinklenberg
(J)
Edward Zamrini
(E)
Christine M. Belden
(CM)
Sherye A. Sirrel
(SA)
Neil Kowall
(N)
Ronald Killiany
(R)
Andrew E. Budson
(AE)
Alexander Norbash
(A)
Patricia Lynn Johnson
(PL)
Thomas O. Obisesan
(TO)
Ntekim E. Oyonumo
(NE)
Joanne Allard
(J)
Olu Ogunlana
(O)
Alan Lerner
(A)
Paula Ogrocki
(P)
Curtis Tatsuoka
(C)
Parianne Fatica
(P)
Evan Fletcher
(E)
Pauline Maillard
(P)
John Olichney
(J)
Charles DeCarli
(C)
None Owen Carmichael
Smita Kittur
(S)
Michael Borrie
(M)
T-Y Lee
(TY)
Rob Bartha
(R)
Sterling Johnson
(S)
Sanjay Asthana
(S)
Cynthia M. Carlsson
(CM)
Pierre Tariot
(P)
Anna Burke
(A)
Joel Hetelle
(J)
Kathryn DeMarco
(K)
Nadira Trncic
(N)
Adam Fleisher
(A)
Stephanie Reeder
(S)
Vernice Bates
(V)
Horacio Capote
(H)
Michelle Rainka
(M)
Douglas W. Scharre
(DW)
Maria Kataki
(M)
Rawan Tarawneh
(R)
Earl A. Zimmerman
(EA)
Dzintra Celmins
(D)
David Hart
(D)
Godfrey D. Pearlson
(GD)
Karen Blank
(K)
Karen Anderson
(K)
Laura A. Flashman
(LA)
Marc Seltzer
(M)
Mary L. Hynes
(ML)
Robert B. Santulli
(RB)
Kaycee M. Sink
(KM)
Mia Yang
(M)
Akiva Mintz
(A)
Brian R. Ott
(BR)
Geoffrey Tremont
(G)
Lori A. Daiello
(LA)
Courtney Bodge
(C)
Stephen Salloway
(S)
Paul Malloy
(P)
Stephen Correia
(S)
Athena Lee
(A)
Howard J. Rosen
(HJ)
Bruce L. Miller
(BL)
David Perry
(D)
Jacobo Mintzer
(J)
Kenneth Spicer
(K)
David Bachman
(D)
Elizabeth Finger
(E)
Stephen Pasternak
(S)
Irina Rachinsky
(I)
John Rogers
(J)
Andrew Kertesz
(A)
Dick Drost
(D)
Nunzio Pomara
(N)
Raymundo Hernando
(R)
Antero Sarrael
(A)
Delwyn D. Miller
(DD)
Karen Ekstam Smith
(K)
Hristina Koleva
(H)
Ki Won Nam
(KW)
Hyungsub Shim
(H)
Susan K. Schultz
(SK)
Norman Relkin
(N)
Gloria Chiang
(G)
Michael Lin
(M)
Lisa Ravdin
(L)
Amanda Smith
(A)
Christi Leach
(C)
Balebail Ashok Raj
(BA)
Kristin Fargher
(K)
Ronald Petersen
(R)
Michael Weiner
(M)
Thomas Neylan
(T)
Jordan Grafman
(J)
Tom Montine
(T)
Gustavo Jimenez
(G)
Jacqueline Hayes
(J)
Shannon Finley
(S)
Danielle Harvey
(D)
Bret Borowski
(B)
Jeff Gunter
(J)
Matt Senjem
(M)
Chad Ward
(C)
Norm Foster
(N)
Eric M. Reiman
(EM)
Kewei Chen
(K)
Susan Landau
(S)
Erin Householder
(E)
Leslie M. Shaw
(LM)
Virginia Lee
(V)
Magdalena Korecka
(M)
Michal Figurski
(M)
Karl Friedl
(K)
Lon S. Schneider
(LS)
Sonia Pawluczyk
(S)
Mauricio Becerra
(M)
James Brewer
(J)
Helen Vanderswag
(H)
Debra Fleischman
(D)
Konstantinos Arfanakis
(K)
Raj C. Shah
(RC)
Ranjan Duara
(R)
Daniel Varon
(D)
Maria T Greig
(MT)
P. Murali Doraiswamy
(PM)
Jeffrey R. Petrella
(JR)
Olga James
(O)
Anton P. Porsteinsson
(AP)
Bonnie Goldstein
(B)
Kimberly S. Martin
(KS)
Steven G. Potkin
(SG)
Adrian Preda
(A)
Dana Nguyen
(D)
Jacobo Mintzer
(J)
Dino Massoglia
(D)
Olga Brawman-Mintzer
(O)
Carl Sadowsky
(C)
Walter Martinez
(W)
Teresa Villena
(T)
Howard Rosen
(H)
David Perry
(D)
Raymond Scott Turner
(R)
Kelly Behan
(K)
Brigid Reynolds
(B)
Reisa A. Sperling
(RA)
Keith A. Johnson
(KA)
Gad Marshall
(G)
Marwan N. Sabbagh
(MN)
Sandra A. Jacobson
(SA)
Sherye A. Sirrel
(SA)
Thomas O. Obisesan
(TO)
Saba Wolday
(S)
Joanne Allard
(J)
Sterling C. Johnson
(SC)
J. Jay Fruehling
(JJ)
Sandra Harding
(S)
Elaine R. Peskind
(ER)
Eric C. Petrie
(EC)
Gail Li
(G)
Jerome A. Yesavage
(JA)
Joy L. Taylor
(JL)
Ansgar J. Furst
(AJ)
Steven Chao
(S)
Norman Relkin
(N)
Gloria Chiang
(G)
Lisa Ravdin
(L)
Informations de copyright
© 2020 American Academy of Neurology.
Références
J Cereb Blood Flow Metab. 2016 Jan;36(1):40-54
pubmed: 25944592
Lancet Neurol. 2013 Aug;12(8):822-38
pubmed: 23867200
Ann Neurol. 2011 Feb;69(2):320-7
pubmed: 21387377
Neurology. 2016 Nov 8;87(19):2043-2049
pubmed: 27605173
Neurology. 2012 Jul 24;79(4):320-6
pubmed: 22786597
Ann Neurol. 2005 Sep;58(3):459-62
pubmed: 16130107
Brain. 2016 Dec;139(Pt 12):3151-3162
pubmed: 27645801
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11050-5
pubmed: 10984517
IEEE Trans Med Imaging. 2007 Apr;26(4):479-86
pubmed: 17427735
Lancet Neurol. 2016 Jul;15(8):811-819
pubmed: 27180034
Neurology. 2014 Aug 26;83(9):794-800
pubmed: 25063759
Stroke. 2004 Nov;35(11 Suppl 1):2616-9
pubmed: 15459438
Magn Reson Imaging. 2009 Oct;27(8):1163-74
pubmed: 19249168
Ann Neurol. 2013 Apr;73(4):529-36
pubmed: 23424091
Neuron. 2002 Jan 31;33(3):341-55
pubmed: 11832223
Neuroimage. 2004 Jul;22(3):1060-75
pubmed: 15219578
Stroke. 2016 Apr;47(4):1146-52
pubmed: 26883497
Stroke. 2016 Aug;47(8):2010-6
pubmed: 27338926
Brain. 2017 Jul 1;140(7):1829-1850
pubmed: 28334869
Lancet Neurol. 2009 Feb;8(2):165-74
pubmed: 19161908
J Magn Reson Imaging. 2008 Apr;27(4):685-91
pubmed: 18302232
Neuroimage. 1999 Feb;9(2):179-94
pubmed: 9931268
J Neurol Neurosurg Psychiatry. 2017 Nov;88(11):982-994
pubmed: 28844070
Neurology. 2013 Nov 5;81(19):1659-65
pubmed: 24097810
Ann Neurol. 2012 Jul;72(1):76-81
pubmed: 22829269
Lancet Neurol. 2016 Jul;15(8):820-829
pubmed: 27133238
Brain. 2015 Jan;138(Pt 1):179-88
pubmed: 25367025
Neurology. 2001 Feb 27;56(4):537-9
pubmed: 11222803
Cereb Cortex. 2009 Mar;19(3):497-510
pubmed: 18632739
Neuroimage. 1999 Feb;9(2):195-207
pubmed: 9931269
Neuroimage. 2012 Aug 15;62(2):774-81
pubmed: 22248573