Synthesis and Structure-Activity Relationship of C-Phenyl D-Glucitol (TP0454614) Derivatives as Selective Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitors.
C-phenyl D-glucitol derivative
heart failure
selective sodium-dependent glucose cotransporter 1 inhibitor
sodium-dependent glucose cotransporter 1
sodium-dependent glucose cotransporter 2
type 2 diabetes
Journal
Chemical & pharmaceutical bulletin
ISSN: 1347-5223
Titre abrégé: Chem Pharm Bull (Tokyo)
Pays: Japan
ID NLM: 0377775
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
3
7
2020
pubmed:
3
7
2020
medline:
2
2
2021
Statut:
ppublish
Résumé
Sodium-glucose cotransporter 1 (SGLT1) is the primary transporter for glucose absorption from the gastrointestinal tract. While C-phenyl D-glucitol derivative SGL5213 has been reported to be a potent intestinal SGLT1 inhibitor for use in the treatment of type 2 diabetes, no SGLT1 selectivity was found in vitro (IC
Identifiants
pubmed: 32611999
doi: 10.1248/cpb.c20-00089
doi:
Substances chimiques
SLC5A1 protein, human
0
Sodium-Glucose Transporter 1
0
Sorbitol
506T60A25R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM