Discovery of a Novel Class of State-Dependent Na

Animals Dose-Response Relationship, Drug Drug Discovery Humans Male Mice Molecular Structure NAV1.7 Voltage-Gated Sodium Channel / metabolism Neuralgia / drug therapy Structure-Activity Relationship Voltage-Gated Sodium Channel Blockers / chemical synthesis
central nervous system (CNS) side effect pain quinolone urethane voltage-gated sodium channel

Journal

Chemical & pharmaceutical bulletin
ISSN: 1347-5223
Titre abrégé: Chem Pharm Bull (Tokyo)
Pays: Japan
ID NLM: 0377775

Informations de publication

Date de publication:
2020
Historique:
entrez: 3 7 2020
pubmed: 3 7 2020
medline: 2 2 2021
Statut: ppublish

Résumé

The discovery of a novel class of state-dependent voltage-gated sodium channel (Na

Identifiants

DOI: 10.1248/cpb.c20-00126 PMID: 32612000
pubmed: 32612000
doi: 10.1248/cpb.c20-00126
doi:

Substances chimiques

NAV1.7 Voltage-Gated Sodium Channel 0
SCN9A protein, human 0
Voltage-Gated Sodium Channel Blockers 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

653-663

Auteurs

Kyosuke Tanaka (K)

R&D Division, Daiichi Sankyo Co., Ltd.

Hiroyuki Kobayashi (H)

R&D Division, Daiichi Sankyo Co., Ltd.

Sayaka Suzuki (S)

R&D Division, Daiichi Sankyo Co., Ltd.

Satoshi Shibuya (S)

R&D Division, Daiichi Sankyo Co., Ltd.

Hiroko Kimoto (H)

R&D Division, Daiichi Sankyo Co., Ltd.

Yuki Domon (Y)

R&D Division, Daiichi Sankyo Co., Ltd.

Kazufumi Kubota (K)

R&D Division, Daiichi Sankyo Co., Ltd.

Yutaka Kitano (Y)

R&D Division, Daiichi Sankyo Co., Ltd.

Tomihisa Yokoyama (T)

R&D Division, Daiichi Sankyo Co., Ltd.

Akiko Shimizugawa (A)

R&D Division, Daiichi Sankyo Co., Ltd.

Ryuta Koishi (R)

Daiichi Sankyo RD Novare Co., Ltd.

Chie Fujiwara (C)

R&D Division, Daiichi Sankyo Co., Ltd.

Daigo Asano (D)

R&D Division, Daiichi Sankyo Co., Ltd.

Tsuyoshi Shinozuka (T)

R&D Division, Daiichi Sankyo Co., Ltd.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Discovery of a Novel Class of State-Dependent Na
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Discovery of a Novel Class of State-Dependent Na
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Discovery of a Novel Class of State-Dependent Na
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Discovery of a Novel Class of State-Dependent Na
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Discovery of a Novel Class of State-Dependent Na
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Discovery of a Novel Class of State-Dependent Na
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Canaux sodiques voltage-dépendants › Canal sodique voltage-dépendant NAV1.7 › Discovery of a Novel Class of State-Dependent Na
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Névralgie › Discovery of a Novel Class of State-Dependent Na
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Discovery of a Novel Class of State-Dependent Na
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Bloqueurs de canaux sodiques › Bloqueurs de canaux sodiques voltage-dépendants › Discovery of a Novel Class of State-Dependent Na