A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome.
Animals
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
/ chemistry
Birt-Hogg-Dube Syndrome
/ genetics
Cell Line
Disease Models, Animal
Enzyme Activation
HeLa Cells
Humans
Kidney Neoplasms
/ metabolism
Mechanistic Target of Rapamycin Complex 1
/ metabolism
Mice
Mice, Knockout
Monomeric GTP-Binding Proteins
/ metabolism
Phosphorylation
Protein Binding
Proto-Oncogene Proteins
/ deficiency
Ras Homolog Enriched in Brain Protein
/ metabolism
Substrate Specificity
Tuberous Sclerosis Complex 2 Protein
/ metabolism
Tumor Suppressor Proteins
/ deficiency
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
03
12
2019
accepted:
27
04
2020
pubmed:
3
7
2020
medline:
21
10
2020
entrez:
3
7
2020
Statut:
ppublish
Résumé
The mechanistic target of rapamycin complex 1 (mTORC1) is a key metabolic hub that controls the cellular response to environmental cues by exerting its kinase activity on multiple substrates
Identifiants
pubmed: 32612235
doi: 10.1038/s41586-020-2444-0
pii: 10.1038/s41586-020-2444-0
pmc: PMC7610377
mid: EMS114552
doi:
Substances chimiques
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
0
Bhd protein, mouse
0
Proto-Oncogene Proteins
0
RHEB protein, human
0
RRAGC protein, human
0
RRAGD protein, human
0
Ras Homolog Enriched in Brain Protein
0
TFEB protein, human
0
TSC2 protein, human
0
Tcfeb protein, mouse
0
Tuberous Sclerosis Complex 2 Protein
0
Tumor Suppressor Proteins
0
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Monomeric GTP-Binding Proteins
EC 3.6.5.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
597-602Subventions
Organisme : European Research Council
ID : 694282
Pays : International
Organisme : NINDS NIH HHS
ID : R01 NS078072
Pays : United States
Commentaires et corrections
Type : CommentIn
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