Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Corneal Ulcer: A Resting-State fMRI Study.
corneal ulcer
functional magnetic resonance imaging
primary visual cortex
resting state
spontaneous brain activity
Journal
Neuropsychiatric disease and treatment
ISSN: 1176-6328
Titre abrégé: Neuropsychiatr Dis Treat
Pays: New Zealand
ID NLM: 101240304
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
11
2019
accepted:
06
06
2020
entrez:
3
7
2020
pubmed:
3
7
2020
medline:
3
7
2020
Statut:
epublish
Résumé
To investigate differences in the functional connectivity (FC) of the primary visual cortex between patients with corneal ulcer (CU) and healthy controls (HCs) using resting-state functional magnetic resonance imaging. A total of 30 patients with CU and 30 HCs were closely matched in terms of sex, age, and level of education. Two-sample The CU group showed significantly elevated FC in the left and right middle frontal gyri and lower FC with the right cuneus compared with the HC group. In addition, the FC of the right cingulate and left superior frontal gyri also increased in the CU group. The receiver operating characteristic curve revealed high diagnostic value in those brain regions. CU involves aberrant FC of the primary visual cortex in different brain areas, including visual-related and cognitive-related regions. This finding may unveil the underlying neural mechanisms of impaired visual function in CU.
Identifiants
pubmed: 32612359
doi: 10.2147/NDT.S238463
pii: 238463
pmc: PMC7323573
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1571-1581Informations de copyright
© 2020 Hu et al.
Déclaration de conflit d'intérêts
This was not an industry-supported study. The authors report no conflicts of interest in this work.
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