Neuromechanisms of SARS-CoV-2: A Review.
COVID-19
SARS-CoV-2
anosmia
central nervous system
dysgeusia
peripheral nervous system
Journal
Frontiers in neuroanatomy
ISSN: 1662-5129
Titre abrégé: Front Neuroanat
Pays: Switzerland
ID NLM: 101477943
Informations de publication
Date de publication:
2020
2020
Historique:
received:
02
05
2020
accepted:
03
06
2020
entrez:
3
7
2020
pubmed:
3
7
2020
medline:
3
7
2020
Statut:
epublish
Résumé
Recent studies have suggested the neuroinvasive potential of severe acute respiratory coronavirus 2 (SARS-CoV-2). Notably, neuroinvasiveness might be involved in the pathophysiology of coronavirus disease 2019 (COVID-19). Some studies have demonstrated that synapse-connected routes may enable coronaviruses to access the central nervous system (CNS). However, evidence related to the presence of SARS-CoV-2 in the CNS, its direct impact on the CNS, and the contribution to symptoms suffered, remain sparse. Here, we review the current literature that indicates that SARS-CoV-2 can invade the nervous system. We also describe the neural circuits that are potentially affected by the virus and their possible role in the progress of COVID-19. In addition, we propose several strategies to understand, diagnose, and treat the neurological symptoms of COVID-19.
Identifiants
pubmed: 32612515
doi: 10.3389/fnana.2020.00037
pmc: PMC7308495
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
37Informations de copyright
Copyright © 2020 DosSantos, Devalle, Aran, Capra, Roque, Coelho-Aguiar, Spohr, Subilhaga, Pereira, D'Andrea Meira, Niemeyer Soares Filho and Moura-Neto.
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