Nasal IgE in subjects with allergic and non-allergic rhinitis.
AR, allergic rhinitis
AR + HDM, allergic rhinitis with house dust mite allergy
Allergic rhinitis
D1, Dermatophagoides pteronyssinus
D2, Dermatophagoides farinae
FEV1, forced expiratory volume in one second
FVC, forced vital capacity
GCP, Good Clinical Practice
HDM, house dust mite
House dust mite allergy
ISAAC, International Study of Asthma and Allergies in Childhood questionnaire
LAR, local allergic rhinitis
Local IgE
Local allergic rhinitis
NARES, non-allergic rhinitis with eosinophilia-syndrome
NPT, nasal provocation tests
Non-allergic-rhinitis
PNIF, peak nasal inspiratory flow
RAST, Radioallergosorbent Test
SD, standard deviation
SPT, skin prick test
sIgE, allergen-specific IgE
Journal
The World Allergy Organization journal
ISSN: 1939-4551
Titre abrégé: World Allergy Organ J
Pays: United States
ID NLM: 101481283
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
13
11
2019
revised:
09
05
2020
accepted:
12
05
2020
entrez:
3
7
2020
pubmed:
3
7
2020
medline:
3
7
2020
Statut:
epublish
Résumé
The prevalence of "ocal allergic rhinitis" within individuals suffering from perennial rhinitis remains uncertain, and patients usually are diagnosed with non-allergic rhinitis. The aim of this study was to evaluate the prevalence of a potential "local allergic rhinitis" in subjects suffering from non-allergic rhinitis in a non-selected group of young students. 131 students (age 25.0 ± 5.1 years) with a possible allergic rhinitis and 25 non-allergic controls without rhinitis symptoms (age 22.0 ± 2.0 years) were recruited by public postings. 97 of 131 students with rhinitis were tested positive (≥3 mm) to prick testing with 17 frequent allergens at visit 1. Twenty-four 24 subjects with a house dust mite allergy, 21 subjects with a non-allergic rhinitis, and 18 non-allergic controls were further investigated at visit 2. Blood samples were taken, and nasal secretion was examined. In addition, all groups performed a nasal provocation test with house dust mite (HDM). In serum and nasal secretion, total IgE and house dust mite specific IgE significantly differed between HDM positive subjects and controls. However, no differences between non-allergic subjects and control subjects were quantifiable. Neither a nasal provocation test nor a nasal IgE to HDM allergens showed a measurable positive response in any of the non-allergic rhinitis subjects as well as the healthy controls, whilst being positive in 13 subjects with HDM allergy. Nasal IgE is present in subjects with HDM allergy, but not in non-allergic rhinitis. In the investigated non-selected population, exclusive local production of IgE is absent. By implication, therefore, our findings challenge the emerging concept of local allergic rhinitis.Study identifier at ClinicalTrials.gov: NCT02810535.
Identifiants
pubmed: 32612737
doi: 10.1016/j.waojou.2020.100129
pii: S1939-4551(20)30032-6
pii: 100129
pmc: PMC7322186
doi:
Banques de données
ClinicalTrials.gov
['NCT02810535']
Types de publication
Journal Article
Langues
eng
Pagination
100129Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
The authors report no competing interests.
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