Independent Prognostic Value of Intratumoral Heterogeneity and Immune Response Features by Automated Digital Immunohistochemistry Analysis in Early Hormone Receptor-Positive Breast Carcinoma.
Ki67
SATB1
breast cancer
digital pathology
immune response
immunohistochemistry
intratumoral heterogeneity
progesterone receptor
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
23
02
2020
accepted:
14
05
2020
entrez:
3
7
2020
pubmed:
3
7
2020
medline:
3
7
2020
Statut:
epublish
Résumé
Immunohistochemistry (IHC) for ER, PR, HER2, and Ki67 is used to predict outcome and therapy response in breast cancer patients. The current IHC assessment, visual or digital, is based mostly on global biomarker expression levels in the tissue sample. In our study, we explored the prognostic value of digital image analysis of conventional breast cancer IHC biomarkers supplemented with their intratumoral heterogeneity and tissue immune response indicators. Surgically excised tumor samples from 101 female patients with hormone receptor-positive breast cancer (HRBC) were stained for ER, PR, HER2, Ki67, SATB1, CD8, and scanned at 20x. Digital image analysis was performed using the HALO™ platform. Subsequently, hexagonal tiling was used to compute intratumoral heterogeneity indicators for ER, PR and Ki67 expression. Multiple Cox regression analysis revealed three independent predictors of the patient's overall survival: Haralick's texture entropy of PR (
Identifiants
pubmed: 32612954
doi: 10.3389/fonc.2020.00950
pmc: PMC7308549
doi:
Types de publication
Journal Article
Langues
eng
Pagination
950Informations de copyright
Copyright © 2020 Zilenaite, Rasmusson, Augulis, Besusparis, Laurinaviciene, Plancoulaine, Ostapenko and Laurinavicius.
Références
Clin Breast Cancer. 2014 Aug;14(4):258-64
pubmed: 24325948
Comput Biol Med. 2015 Feb;57:123-9
pubmed: 25553357
Cancer Sci. 2013 Nov;104(11):1539-43
pubmed: 23905924
Am J Clin Pathol. 2014 May;141(5):697-701
pubmed: 24713741
J Leukoc Biol. 2019 Feb;105(2):243-255
pubmed: 30387907
BMC Cancer. 2018 Mar 24;18(1):320
pubmed: 29573739
Genes Dev. 2000 Mar 1;14(5):521-35
pubmed: 10716941
Mod Pathol. 2018 Feb;31(2):214-234
pubmed: 29192647
BMC Cancer. 2018 Oct 1;18(1):938
pubmed: 30285668
J Neuroimmunol. 2013 Nov 15;264(1-2):71-83
pubmed: 24045166
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Virchows Arch. 2015 Oct 19;:
pubmed: 26481244
Science. 2006 Sep 29;313(5795):1960-4
pubmed: 17008531
Mod Pathol. 2016 Apr;29(4):318-29
pubmed: 26916072
Int J Cancer. 2005 Sep 1;116(3):340-50
pubmed: 15818618
JAMA Oncol. 2016 Oct 1;2(10):1354-1360
pubmed: 27355489
Nature. 2002 Jan 31;415(6871):530-6
pubmed: 11823860
Ann Oncol. 2013 Sep;24(9):2206-23
pubmed: 23917950
Breast Cancer Res Treat. 2002 Nov;76(1):65-71
pubmed: 12408377
J Clin Oncol. 2020 Apr 20;38(12):1346-1366
pubmed: 31928404
Blood. 2009 Aug 20;114(8):1537-44
pubmed: 19423728
Arch Pathol Lab Med. 2010 Jun;134(6):907-22
pubmed: 20524868
J Natl Cancer Inst. 2011 Nov 16;103(22):1656-64
pubmed: 21960707
Mod Pathol. 2019 Sep;32(9):1244-1256
pubmed: 30976105
Nature. 2008 Mar 13;452(7184):187-93
pubmed: 18337816
J Transl Med. 2012 Oct 03;10:205
pubmed: 23034130
Ann Oncol. 2014 Aug;25(8):1536-43
pubmed: 24915873
Diagn Pathol. 2016 Aug 30;11(1):82
pubmed: 27576949
Onco Targets Ther. 2018 Aug 08;11:4673-4683
pubmed: 30122958
Breast Cancer Res Treat. 2019 Jul;176(1):27-36
pubmed: 30997625
Nature. 2000 Aug 17;406(6797):747-52
pubmed: 10963602
J Clin Oncol. 2011 Nov 10;29(32):4273-8
pubmed: 21990413
Anal Cell Pathol (Amst). 2012;35(2):75-8
pubmed: 21971321
Immunity. 2017 Jan 17;46(1):3-5
pubmed: 28099863
Immunol Cell Biol. 2019 May;97(5):498-511
pubmed: 30803026
N Engl J Med. 2016 Nov 10;375(19):1823-1833
pubmed: 27718847
Nat Med. 2016 Jan;22(1):105-13
pubmed: 26618723
Oncotarget. 2015 Dec 1;6(38):41134-45
pubmed: 26512778
J Clin Oncol. 2012 Mar 1;30(7):729-34
pubmed: 22291085
Comput Biol Med. 2010 Mar;40(3):318-30
pubmed: 20106472
PLoS One. 2012;7(12):e51862
pubmed: 23251644
Adv Surg. 2008;42:249-60
pubmed: 18953822
Cancers (Basel). 2019 Aug 22;11(9):
pubmed: 31443339
Br J Cancer. 2007 May 21;96(10):1504-13
pubmed: 17453008
Nat Commun. 2018 Oct 16;9(1):4297
pubmed: 30327458
Nat Med. 2018 May;24(5):541-550
pubmed: 29686425
Blood. 2010 Sep 2;116(9):1443-53
pubmed: 20522714
Immunity. 2017 Jan 17;46(1):51-64
pubmed: 28099864
Cell. 2016 Mar 10;164(6):1233-1247
pubmed: 26967289
N Engl J Med. 2015 Oct 22;373(17):1627-39
pubmed: 26412456
Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11462-7
pubmed: 11562467
Cancer Res. 2007 Jan 1;67(1):354-61
pubmed: 17210718
Breast Cancer Res. 2014;16(2):R35
pubmed: 24708745
Mod Pathol. 2019 Jan;32(1):59-69
pubmed: 30143750
Virchows Arch. 2016 Apr;468(4):493-502
pubmed: 26818835
J Natl Cancer Inst. 2013 Dec 18;105(24):1897-906
pubmed: 24203987
Oncotarget. 2017 Feb 28;8(9):15621-15631
pubmed: 28152503
Lancet Oncol. 2018 Jan;19(1):40-50
pubmed: 29233559
Breast Cancer Res. 2019 Aug 7;21(1):90
pubmed: 31391067
J Pathol. 2014 Jan;232(2):199-209
pubmed: 24122236
Oncol Lett. 2019 Mar;17(3):2647-2656
pubmed: 30867728
Cancer. 2012 Mar 15;118(6):1498-506
pubmed: 21837669
Histopathology. 2016 Jul;69(1):25-34
pubmed: 26588661
J Clin Pathol. 2000 Feb;53(2):125-30
pubmed: 10767828
Nature. 2002 Dec 19-26;420(6917):860-7
pubmed: 12490959
Nat Rev Cancer. 2012 Mar 15;12(4):298-306
pubmed: 22419253
J Clin Oncol. 2011 Apr 20;29(12):1531-8
pubmed: 21422407
Hum Pathol. 2016 Jan;47(1):78-84
pubmed: 26541326
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10869-74
pubmed: 11553815
Nat Rev Cancer. 2013 Nov;13(11):759-71
pubmed: 24154716
Arch Pathol Lab Med. 2007;131(1):18-43
pubmed: 19548375
J Transl Med. 2016 Jun 10;14(1):173
pubmed: 27286842
J Clin Oncol. 2009 Dec 10;27(35):5944-51
pubmed: 19858404
JAMA Oncol. 2015 Jul;1(4):448-54
pubmed: 26181252
Histopathology. 2011 Jun;58(7):1107-16
pubmed: 21707712
Pathol Res Pract. 2018 Dec;214(12):2087-2092
pubmed: 30377025
J Thorac Oncol. 2017 May;12(5):791-803
pubmed: 28088513
J Natl Cancer Inst. 2016 Apr 29;108(9):
pubmed: 27130929
J Pathol Inform. 2019 Mar 08;10:9
pubmed: 30984469
Science. 2016 May 6;352(6286):658-60
pubmed: 27151852
Eur Urol. 2019 Mar;75(3):435-444
pubmed: 30274701
Transl Res. 2018 Apr;194:19-35
pubmed: 29175265
Nat Genet. 2003 May;34(1):42-51
pubmed: 12692553
Clin Breast Cancer. 2018 Feb;18(1):1-8
pubmed: 28712925
Cancer Res Treat. 2019 Jul;51(3):1086-1097
pubmed: 30428640
Cancer Immunol Immunother. 2014 Apr;63(4):395-406
pubmed: 24514954
PLoS One. 2017 Feb 10;12(2):e0172031
pubmed: 28187177
Nat Med. 2002 Nov;8(11):1323-7
pubmed: 12389040
Appl Immunohistochem Mol Morphol. 2007 Jun;15(2):124-33
pubmed: 17525622
Nat Rev Clin Oncol. 2016 Apr;13(4):228-41
pubmed: 26667975
Diagn Pathol. 2012 Mar 16;7:27
pubmed: 22424533
Immunity. 2013 Jun 27;38(6):1105-15
pubmed: 23791645
Eur J Breast Health. 2017 Oct 01;13(4):168-174
pubmed: 29082373
J Thorac Oncol. 2011 Jul;6(7):1179-89
pubmed: 21597389
Breast. 2020 Feb;49:225-232
pubmed: 31911370
J Natl Cancer Inst. 2010 Aug 18;102(16):1284-96
pubmed: 20595686
J Virol. 2007 Sep;81(17):9249-58
pubmed: 17567698
PLoS One. 2014 Apr 17;9(4):e95475
pubmed: 24743335
World J Clin Oncol. 2016 Oct 10;7(5):387-394
pubmed: 27777881
Curr Opin Immunol. 2010 Apr;22(2):223-30
pubmed: 20207527
Cancer J. 2018 Jan/Feb;24(1):15-19
pubmed: 29360723