Multiparametric MRI characterization of level dependent differences in lumbar muscle size, quality, and microstructure.
MRI
diffusion tensor imaging
fatty infiltration
lumbar spine
skeletal muscle
Journal
JOR spine
ISSN: 2572-1143
Titre abrégé: JOR Spine
Pays: United States
ID NLM: 101722350
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
23
10
2019
revised:
09
01
2020
accepted:
13
01
2020
entrez:
3
7
2020
pubmed:
3
7
2020
medline:
3
7
2020
Statut:
epublish
Résumé
Magnetic resonance imaging (MRI) is a diagnostic tool that can be used to noninvasively assess lumbar muscle size and fatty infiltration, important biomarkers of muscle health. Diffusion tensor imaging (DTI) is an MRI technique that is sensitive to muscle microstructural features such as fiber size (an important biomarker of muscle health), which is typically only assessed using invasive biopsy techniques. The goal of this study was to establish normative values of level-dependent lumbar muscle size, fat signal fraction, and restricted diffusion assessed by MRI in a highly active population. Forty-two active-duty Marines were imaged using a (a) high-resolution anatomical, (b) fat-water separation, and (c) DT-MRI scan. The multifidus and erector spinae muscles were compared at each level using two-way repeated measures ANOVA. Secondary analysis included Three dimensional (3D) reconstructions to qualitatively assess lumbar muscle size, fatty infiltration, and fiber orientation via tractography. The erector spinae was found to be larger than the multifidus above L5, with lower fat signal fraction above L3, and a less restricted diffusion profile than the multifidus above L4, with this pattern reversed in the lower lumbar spine. 3D reconstructions demonstrated accumulations of epimuscular fat in the anterior and posterior regions of the lumbar musculature, with minimal intramuscular fatty infiltration. Tractography images demonstrated different orientations of adjacent lumbar musculature, which cannot be visualized with standard MRI pulse sequences. The level dependent differences found in this study provide a normative baseline, for which to better understand whole muscle and microstructural changes associated with aging, low back pain, and pathology.
Identifiants
pubmed: 32613159
doi: 10.1002/jsp2.1079
pii: JSP21079
pmc: PMC7323468
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e1079Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR070830
Pays : United States
Informations de copyright
© 2020 The Authors. JOR Spine published by Wiley Periodicals, Inc. on behalf of Orthopaedic Research Society.
Déclaration de conflit d'intérêts
The authors declare no competing conflict of interest.
Références
J Biomech. 2012 May 11;45(8):1507-13
pubmed: 22406468
J Anat. 1999 Jan;194 ( Pt 1):79-88
pubmed: 10227669
Magn Reson Med. 2002 Jul;48(1):97-104
pubmed: 12111936
J Bone Joint Surg Am. 2009 Jan;91(1):176-85
pubmed: 19122093
J Exp Biol. 2010 Aug 1;213(Pt 15):2582-8
pubmed: 20639419
J Orthop Sports Phys Ther. 1998 Jun;27(6):389-402
pubmed: 9617724
Magn Reson Med. 2005 Sep;54(3):636-44
pubmed: 16092103
Ann Neurol. 1999 Feb;45(2):265-9
pubmed: 9989633
J Appl Physiol (1985). 2011 Mar;110(3):807-19
pubmed: 21164150
AJNR Am J Neuroradiol. 2016 Apr;37(4):742-8
pubmed: 26635285
Asian Spine J. 2013 Dec;7(4):322-34
pubmed: 24353850
NMR Biomed. 2009 Dec;22(10):1047-53
pubmed: 19618408
J Appl Physiol (1985). 2007 Aug;103(2):673-81
pubmed: 17446411
Acta Orthop Scand Suppl. 1989;230:1-54
pubmed: 2658468
Clin Spine Surg. 2016 Apr;29(3):E139-45
pubmed: 27007789
BMC Musculoskelet Disord. 2018 May 7;19(1):135
pubmed: 29734942
Sports Med. 2014 Oct;44(10):1439-58
pubmed: 25015476
J Comput Assist Tomogr. 2013 Jan-Feb;37(1):98-104
pubmed: 23321840
J Appl Physiol (1985). 1994 Sep;77(3):1439-44
pubmed: 7836150
BMC Musculoskelet Disord. 2017 Jan 19;18(1):25
pubmed: 28103921
World Neurosurg. 2019 Feb;122:e1069-e1077
pubmed: 30415054
Magn Reson Med. 2018 Jul;80(1):317-329
pubmed: 29090480
J Magn Reson Imaging. 2016 Apr;43(4):773-88
pubmed: 26221741
Spine (Phila Pa 1976). 2012 Dec 15;37(26):E1651-8
pubmed: 23023592
Eur J Morphol. 1996;34(1):5-10
pubmed: 8743092
J Magn Reson Imaging. 2013 Nov;38(5):1292-7
pubmed: 23418124
Eur Radiol. 2008 Oct;18(10):2303-10
pubmed: 18463875
Spine (Phila Pa 1976). 1993 Jun 1;18(7):830-6
pubmed: 8316880
J Orthop Sports Phys Ther. 2018 Aug;48(8):613-621
pubmed: 29772956
Eur Spine J. 1996;5(3):193-7
pubmed: 8831123
Muscle Nerve. 2018 Feb;57(2):200-205
pubmed: 28271516
Med Sci Sports Exerc. 2001 May;33(5):783-90
pubmed: 11323549
Spine (Phila Pa 1976). 2015 Jul 15;40(14):1057-71
pubmed: 25943090
Spine (Phila Pa 1976). 1992 Aug;17(8):897-913
pubmed: 1523493
J Orthop Res. 2016 Dec;34(12):2089-2095
pubmed: 27061583
Neuroimage. 2003 Oct;20(2):870-88
pubmed: 14568458
J Orthop Res. 2017 Oct;35(10):2145-2153
pubmed: 28052435
Magn Reson Med. 2006 Aug;56(2):272-81
pubmed: 16826605
J Appl Physiol Respir Environ Exerc Physiol. 1984 Dec;57(6):1715-21
pubmed: 6511546
NMR Biomed. 2002 Nov-Dec;15(7-8):468-80
pubmed: 12489096
Comput Biomed Res. 1996 Jun;29(3):162-73
pubmed: 8812068
J Biomech. 2019 Mar 27;86:71-78
pubmed: 30739766
J Digit Imaging. 2004 Sep;17(3):205-16
pubmed: 15534753
Spine (Phila Pa 1976). 2017 Apr 15;42(8):616-623
pubmed: 27517512
Neuroimage. 2004;23 Suppl 1:S208-19
pubmed: 15501092
BMC Musculoskelet Disord. 2018 Sep 27;19(1):351
pubmed: 30261870
Philos Trans R Soc Lond B Biol Sci. 2011 May 27;366(1570):1466-76
pubmed: 21502118
BMC Med. 2007 Jan 25;5:2
pubmed: 17254322
Br J Sports Med. 2001 Jun;35(3):186-91
pubmed: 11375879
J Magn Reson Imaging. 2019 Sep;50(3):816-823
pubmed: 30723976
J Anat. 1989 Apr;163:243-7
pubmed: 2606776