Potential role of mitochondria in synoviocytes.
Fibroblast-like synoviocytes (FLS)
Macrophage-like synoviocytes (MLS)
Mitochondria
Osteoarthritis
Rheumatoid arthritis
Synoviocytes
Journal
Clinical rheumatology
ISSN: 1434-9949
Titre abrégé: Clin Rheumatol
Pays: Germany
ID NLM: 8211469
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
16
04
2020
accepted:
23
06
2020
revised:
20
06
2020
pubmed:
3
7
2020
medline:
15
5
2021
entrez:
3
7
2020
Statut:
ppublish
Résumé
Synoviocytes are located in the synovium lining layer, which is composed of macrophage-like synoviocytes (MLS) and fibroblast-like synoviocytes (FLS) with different characteristics. Mitochondria, which exist in most cells, are two membrane-covered organelles. In addition to providing the necessary ATP for synoviocytes, mitochondria are involved in the regulation of redox homeostasis and the integration of synoviocytes death signals. In recent years, mitochondrial dysfunction has been found in rheumatoid arthritis (RA) and osteoarthritis (OA). Interestingly, recent studies have started uncovering that mitochondria that were previously reported to play a role in chondrocytes or immune cells, but not known to have pronounced roles in synoviocytes, can actually play crucial roles in the regulation of the pathological properties of the synoviocytes. The purpose of this review is to summarize our current understanding of the key role of mitochondria in synoviocytes, including mitochondrial dysfunction in synoviocytes can induce and aggravate inflammatory responses and changes in mitochondrial structure and function with the involvement of multiple cytokines, signal pathway, and hypoxic state of synovial tissue alter the response of synoviocytes to apoptotic stimulation. Also, mitochondrial abnormalities in synoviocytes promote the synoviocytes invasion and proliferation.
Identifiants
pubmed: 32613391
doi: 10.1007/s10067-020-05263-5
pii: 10.1007/s10067-020-05263-5
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
447-457Subventions
Organisme : Science and Technology Innovation Program in Hunan province
ID : 2018SK2077
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