[Photoreceptor cell transplantation for future treatment of retinitis pigmentosa].
Nouvelle approche thérapeutique pour les rétinites pigmentaires - La transplantation de photorécepteurs dérivés de cellules souches.
Animals
Humans
Induced Pluripotent Stem Cells
/ cytology
Organoids
/ cytology
Photoreceptor Cells
/ cytology
Pluripotent Stem Cells
/ cytology
Retina
/ cytology
Retinal Degeneration
/ therapy
Retinitis Pigmentosa
/ pathology
Severity of Illness Index
Therapies, Investigational
/ methods
Tissue Culture Techniques
Tissue and Organ Harvesting
/ methods
Journal
Medecine sciences : M/S
ISSN: 1958-5381
Titre abrégé: Med Sci (Paris)
Pays: France
ID NLM: 8710980
Informations de publication
Date de publication:
Historique:
entrez:
3
7
2020
pubmed:
3
7
2020
medline:
10
10
2020
Statut:
ppublish
Résumé
In inherited retinal diseases such retinitis pigmentosa, characterized by progressive loss of light sensitive neurons (photoreceptors), cell therapy is now considered as an attractive strategy. Photoreceptor cell replacement would be valuable for restoring function to retinas in a way that is independent from the cause of the disease. With advances in stem cell biology, considerable strides have been made towards the generation of retinal cells, in particular with the development of 3D culture systems allowing the generation of retinal organoids from pluripotent stem cells. In this review, we present a state-of-the art of preclinical strategies conducted in animal models for photoreceptor replacement from stem cell-derived photoreceptors and we discuss the important obstacles to overcome in the future. Nouvelle approche thérapeutique pour les rétinites pigmentaires - La transplantation de photorécepteurs dérivés de cellules souches. Dans les maladies dégénératives de la rétine affectant les photorécepteurs, la transplantation de cellules permettant la restauration de la vision est aujourd’hui envisagée. La dernière décennie a vu des progrès remarquables dans la génération de cellules de rétine à partir de cellules souches pluripotentes humaines avec, en particulier, le développement de systèmes de culture en trois dimensions (3D) permettant la génération d’organoïdes de rétine. Dans cette revue, nous faisons un état des lieux sur les stratégies précliniques menées dans des modèles animaux pour le remplacement des photorécepteurs par des photorécepteurs dérivés de cellules souches et présentons les obstacles importants qui restent à être surmontés.
Autres résumés
Type: Publisher
(fre)
Nouvelle approche thérapeutique pour les rétinites pigmentaires - La transplantation de photorécepteurs dérivés de cellules souches.
Identifiants
pubmed: 32614311
doi: 10.1051/medsci/2020097
pii: msc200073
doi:
Types de publication
Journal Article
Review
Langues
fre
Sous-ensembles de citation
IM
Pagination
600-606Informations de copyright
© 2020 médecine/sciences – Inserm.
Références
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