Traceable Peptidic Ligands that Target Ghrelin Receptors.
fluorescence
ghrelin
ghrelin receptor
ligand
peptide
radiolabeling
Journal
Current protein & peptide science
ISSN: 1875-5550
Titre abrégé: Curr Protein Pept Sci
Pays: United Arab Emirates
ID NLM: 100960529
Informations de publication
Date de publication:
2020
2020
Historique:
received:
23
03
2020
revised:
18
05
2020
accepted:
18
05
2020
pubmed:
3
7
2020
medline:
26
5
2021
entrez:
3
7
2020
Statut:
ppublish
Résumé
Ghrelin is a 28-amino acid octanoylated peptide hormone that is implicated in many physiological and pathophysiological processes. Specific visualization of ghrelin and its cognate receptor using traceable ligands is crucial in elucidating the localization, functions, and expression pattern of the peptide's signaling pathway. Here 12 representative radio- and fluorescently-labeled peptide-based ligands are reviewed for in vitro and in vivo imaging studies. In particular, the focus is on their structural features, pharmacological properties, and applications in further biochemical research.
Identifiants
pubmed: 32614744
pii: CPPS-EPUB-107853
doi: 10.2174/1389203721666200702131457
doi:
Substances chimiques
Fluorescent Dyes
0
Ghrelin
0
Ligands
0
Peptides
0
Receptors, Ghrelin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
955-964Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.