The emerging role and significance of circular RNAs in viral infections and antiviral immune responses: possible implication as theranostic agents.
Animals
Biomarkers
/ analysis
Bovine Virus Diarrhea-Mucosal Disease
/ genetics
Cattle
Coronavirus Infections
/ genetics
HIV Infections
/ genetics
Hepatitis C
/ genetics
Herpesviridae Infections
/ genetics
Host-Pathogen Interactions
/ genetics
Humans
Influenza, Human
/ genetics
Precision Medicine
/ methods
RNA Viruses
/ genetics
RNA, Circular
/ immunology
Swine
Swine Diseases
/ virology
Virus Diseases
/ genetics
Non-coding RNAs
antiviral immune responses
circular RNAs
rna sequencing
viral infections
Journal
RNA biology
ISSN: 1555-8584
Titre abrégé: RNA Biol
Pays: United States
ID NLM: 101235328
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
pubmed:
3
7
2020
medline:
29
1
2021
entrez:
3
7
2020
Statut:
ppublish
Résumé
Circular RNAs (circRNAs) are ubiquitously expressed, covalently closed rings, produced by pre-mRNA splicing in a reversed order during post-transcriptional processing. Circularity endows 3'-5'-linked circRNAs with stability and resistance to exonucleolytic degradation which raises the question whether circRNAs may be relevant as potential therapeutic targets or agents. High stability in biological systems is the most remarkable property and a major criterion for why circRNAs could be exploited for a range of RNA-centred medical applications. Even though various biological roles and regulatory functions of circRNAs have been reported, their in-depth study is challenging because of their circular structure and sequence-overlap with linear mRNA counterparts. Moreover, little is known about their role in viral infections and in antiviral immune responses. We believe that an in-depth and detailed understanding of circRNA mediated viral protein regulations will increase our knowledge of the biology of these novel molecules. In this review, we aimed to provide a comprehensive basis and overview on the biogenesis, significance and regulatory roles of circRNAs in the context of antiviral immune responses and viral infections including hepatitis C virus infection, hepatitis B virus infection, hepatitis delta virus infection, influenza A virus infection, Epstein-Barr virus infection, kaposi's sarcoma herpesvirus infection, human cytomegalovirus infection, herpes simplex virus infection, human immunodeficiency virus infection, porcine epidemic diarrhoea virus infection, ORF virus infection, avian leukosis virus infection, simian vacuolating virus 40 infection, transmissible gastroenteritis coronavirus infection, and bovine viral diarrhoea virus infection. We have also discussed the critical regulatory role of circRNAs in provoking antiviral immunity, providing evidence for implications as therapeutic agents and as diagnostic markers.
Identifiants
pubmed: 32615049
doi: 10.1080/15476286.2020.1790198
pmc: PMC7833768
doi:
Substances chimiques
Biomarkers
0
RNA, Circular
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-15Références
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