Molecular signatures identified by integrating gene expression and methylation in non-seminoma and seminoma of testicular germ cell tumours.
Testicular germ cell tumour
co-regulation network
methylation
microRNA
non-seminoma
seminoma
Journal
Epigenetics
ISSN: 1559-2308
Titre abrégé: Epigenetics
Pays: United States
ID NLM: 101265293
Informations de publication
Date de publication:
Historique:
pubmed:
3
7
2020
medline:
13
1
2022
entrez:
3
7
2020
Statut:
ppublish
Résumé
Testicular germ cell tumours (TGCTs) are the most common cancer in young male adults (aged 15 to 40). Unlike most other cancer types, identification of molecular signatures in TGCT has rarely reported. In this study, we developed a novel integrative analysis framework to identify co-methylated and co-expressed genes [mRNAs and microRNAs (miRNAs)] modules in two TGCT subtypes: non-seminoma (NSE) and seminoma (SE). We first integrated DNA methylation and mRNA/miRNA expression data and then used a statistical method, CoMEx (
Identifiants
pubmed: 32615059
doi: 10.1080/15592294.2020.1790108
pmc: PMC7889165
doi:
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
162-176Subventions
Organisme : NLM NIH HHS
ID : R01 LM012806
Pays : United States
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