Polygenic Risk Scores Allow Risk Stratification for Keratinocyte Cancer in Organ-Transplant Recipients.
Biomarkers, Tumor
/ genetics
Carcinoma, Basal Cell
/ epidemiology
Carcinoma, Squamous Cell
/ epidemiology
Case-Control Studies
Datasets as Topic
Female
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Models, Genetic
Organ Transplantation
/ adverse effects
Prospective Studies
Risk Assessment
/ methods
Risk Factors
Skin Neoplasms
/ epidemiology
Transplant Recipients
/ statistics & numerical data
Journal
The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
13
05
2020
revised:
11
06
2020
accepted:
16
06
2020
pubmed:
3
7
2020
medline:
18
9
2021
entrez:
3
7
2020
Statut:
ppublish
Résumé
Organ-transplant recipients have an elevated risk of keratinocyte cancers: basal cell carcinoma (BCC) and squamous cell carcinoma. We assessed whether polygenic risk scores (PRSs) generated in nontransplantees from the UK Biobank and 23andMe (13,981 squamous cell carcinoma, 33,736 BCC, and >560,000 controls) can predict keratinocyte cancer risk in an independent organ-transplant recipient cohort. After adjusting for traditional risk factors, compared with the bottom 20%, organ-transplant recipients in the top 20% PRS had an increased risk of BCC (OR = 3.25, 95% confidence interval = 1.44-7.31, P = 4.4 × 10
Identifiants
pubmed: 32615124
pii: S0022-202X(20)31734-6
doi: 10.1016/j.jid.2020.06.017
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
325-333.e6Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.