Conjunctival microvascular responses to anti-inflammatory treatment in patients with dry eye.
Adult
Aged
Anti-Inflammatory Agents
/ therapeutic use
Blood Flow Velocity
Case-Control Studies
Conjunctiva
/ blood supply
Dry Eye Syndromes
/ diagnosis
Female
Fluorometholone
/ therapeutic use
Hemodynamics
/ drug effects
Humans
Male
Microcirculation
/ drug effects
Middle Aged
Time Factors
Treatment Outcome
Young Adult
Anti-inflammatory
Dry eye
Functional slit-lamp biomicroscopy
Microcirculation
Microvasculature
Journal
Microvascular research
ISSN: 1095-9319
Titre abrégé: Microvasc Res
Pays: United States
ID NLM: 0165035
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
12
11
2019
revised:
17
06
2020
accepted:
17
06
2020
pubmed:
3
7
2020
medline:
26
11
2020
entrez:
3
7
2020
Statut:
ppublish
Résumé
This study characterized conjunctival microvascular morphological and haemodynamic responses after anti-inflammatory treatment in dry eye (DE). Twenty-five patients with moderate DE (17 females and 8 males aged 48 ± 16 years) who underwent anti-inflammatory therapy (0.1% fluorometholone) and 25 healthy subjects (20 females and 5 males aged 48 ± 17 years) recruited as controls were enrolled. The conjunctival blood flow rate (BFR), blood flow velocity (BFV) and vessel diameter were measured by functional slit-lamp biomicroscopy (FSLB). DE symptoms and signs were assessed. All measurements were performed at baseline and at 30 and 60 days after commencement of treatment. At baseline, the conjunctival BFR, BFV, and vessel diameter were higher in the DE group than in the control group (p < 0.05). The BFR, BFV and corneal fluorescein staining (CFS) scores decreased at 60 days after therapy compared to at baseline and 30 days (all p This study characterized conjunctival microvascular responses to anti-inflammatory treatment in DE patients. The results suggest that conjunctival BFV and BFR can be used as dynamic markers for treatment efficacy in DE.
Identifiants
pubmed: 32615134
pii: S0026-2862(20)30093-5
doi: 10.1016/j.mvr.2020.104033
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Fluorometholone
SV0CSG527L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104033Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of competing interest None of the authors of the manuscript have any proprietary interests in any of the materials or methods.