The hepatic lipidome: From basic science to clinical translation.
Lipid droplets
Lipid metabolism
Lipidomics
Liposomes
Liver diseases
Pro-resolving lipids
Steatosis
Journal
Advanced drug delivery reviews
ISSN: 1872-8294
Titre abrégé: Adv Drug Deliv Rev
Pays: Netherlands
ID NLM: 8710523
Informations de publication
Date de publication:
2020
2020
Historique:
received:
16
02
2020
revised:
05
06
2020
accepted:
25
06
2020
pubmed:
3
7
2020
medline:
28
8
2021
entrez:
3
7
2020
Statut:
ppublish
Résumé
The liver is the key organ involved in lipid metabolism and transport. Excessive lipid accumulation due to dysregulated lipid metabolism predisposes the liver to steatosis, cirrhosis, and hepatocellular carcinoma. Lipids are generally compartmentalized in specialized organelles called lipid droplets that enable cells to store and release lipids in a regulated manner. However, during flux-in and flux-out of droplets, lipids are converted into toxic species leading to lipid-mediated liver damage. Lipids are categorized into 'toxic' or 'healthy' lipids that are involved in liver disease pathogenesis or resolution, respectively. Lipidomic analysis have revealed unique lipid signature that correlates with the disease progression therefore being used for disease diagnosis. In this comprehensive review, we provide an overview on hepatic lipid homeostasis, lipid compartmentalization mechanisms and lipidomic profiles in different liver diseases. We further discuss promising therapeutics targeting the hepatic lipidome including pro-resolving lipids, liposomes, and small-molecule inhibitors for the treatment of liver diseases.
Identifiants
pubmed: 32615143
pii: S0169-409X(20)30073-9
doi: 10.1016/j.addr.2020.06.027
pii:
doi:
Substances chimiques
Lipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
180-197Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.