High susceptibility to collagen-induced arthritis in mice with progesterone receptors selectively inhibited in osteoprogenitor cells.

Animals Arthritis, Experimental / chemically induced Collagen Disease Models, Animal Female Male Mice Receptors, Progesterone Sex Characteristics
Inflammatory arthritis Osteoprogenitor cells Progesterone receptor Sex difference Susceptibility

Journal

Arthritis research & therapy
ISSN: 1478-6362
Titre abrégé: Arthritis Res Ther
Pays: England
ID NLM: 101154438

Informations de publication

Date de publication:
02 07 2020
Historique:
received: 11 03 2020
accepted: 09 06 2020
entrez: 4 7 2020
pubmed: 4 7 2020
medline: 22 6 2021
Statut: epublish

Résumé

Progesterone receptor (PR) affects immunomodulation, and lack of PR in osteoprogenitor cells primarily affects pathways associated with immunomodulation, especially in males. In this study, we selectively deleted PR from osteoprogenitor cells using Prx1-Cre to evaluate the tissue-specific effects of PR on the pathegenesis of inflammatary arthritis (IA). Collagen-induced arthritis (CIA) was used as an IA animal model. Both male and female PR Bone erosions developed in both paw joints in 37.5% and 41.7% of the WT and PR The presence of PR in osteoprogenitor cells decreased the development of collagen-induced arthritis and might help to explain the sex differences observed in human inflammatory arthritis.

Sections du résumé

BACKGROUND
Progesterone receptor (PR) affects immunomodulation, and lack of PR in osteoprogenitor cells primarily affects pathways associated with immunomodulation, especially in males. In this study, we selectively deleted PR from osteoprogenitor cells using Prx1-Cre to evaluate the tissue-specific effects of PR on the pathegenesis of inflammatary arthritis (IA).
METHODS
Collagen-induced arthritis (CIA) was used as an IA animal model. Both male and female PR
RESULTS
Bone erosions developed in both paw joints in 37.5% and 41.7% of the WT and PR
CONCLUSIONS
The presence of PR in osteoprogenitor cells decreased the development of collagen-induced arthritis and might help to explain the sex differences observed in human inflammatory arthritis.

Identifiants

DOI: 10.1186/s13075-020-02242-8 PMID: 32616012 PMC: PMC7331177
pubmed: 32616012
doi: 10.1186/s13075-020-02242-8
pii: 10.1186/s13075-020-02242-8
pmc: PMC7331177
doi:

Substances chimiques

Receptors, Progesterone 0
Collagen 9007-34-5

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

165

Subventions

Organisme : NIAMS NIH HHS
ID : 1P50AR063043
Pays : United States

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Auteurs

Lixian Liu (L)

Department of Internal Medicine, University of California, Davis Medical Center, 4625 2nd Avenue, Sacramento, CA, 95817, USA.

Junjing Jia (J)

Department of Internal Medicine, University of California, Davis Medical Center, 4625 2nd Avenue, Sacramento, CA, 95817, USA.
Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, Yunnan, People's Republic of China.

Min Jiang (M)

Department of Internal Medicine, University of California, Davis Medical Center, 4625 2nd Avenue, Sacramento, CA, 95817, USA.

Xueping Liu (X)

Department of Internal Medicine, University of California, Davis Medical Center, 4625 2nd Avenue, Sacramento, CA, 95817, USA.

Chenling Dai (C)

Department of Internal Medicine, University of California, Davis Medical Center, 4625 2nd Avenue, Sacramento, CA, 95817, USA.

Barton L Wise (BL)

Department of Internal Medicine, University of California, Davis Medical Center, 4625 2nd Avenue, Sacramento, CA, 95817, USA.
Department of Orthopaedic Surgery, UC Davis Medical Center, Sacramento, 95817, USA.

Nancy E Lane (NE)

Department of Internal Medicine, University of California, Davis Medical Center, 4625 2nd Avenue, Sacramento, CA, 95817, USA.

Wei Yao (W)

Department of Internal Medicine, University of California, Davis Medical Center, 4625 2nd Avenue, Sacramento, CA, 95817, USA. wy5997686@gmail.com.
ORCID: 0000-0002-1198-1161

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › High susceptibility to collagen-induced...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Arthrite expérimentale › High susceptibility to collagen-induced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Collagène › High susceptibility to collagen-induced...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › High susceptibility to collagen-induced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › High susceptibility to collagen-induced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs à la progestérone › High susceptibility to collagen-induced...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Caractères sexuels › High susceptibility to collagen-induced...