Synthesis and evaluation of new 1-oxa-8-azaspiro[4.5]decane derivatives as candidate radioligands for sigma-1 receptors.
Animals
Aza Compounds
/ chemical synthesis
Brain
/ diagnostic imaging
Dose-Response Relationship, Drug
Fluorine Radioisotopes
/ chemistry
Ligands
Male
Mice
Mice, Inbred ICR
Molecular Structure
Radioligand Assay
Receptors, sigma
/ analysis
Spiro Compounds
/ chemical synthesis
Structure-Activity Relationship
Tissue Distribution
Sigma-1 Receptor
1,5-Dioxa-9-azaspiro[5.5]undecane derivatives
1-Oxa-8-azaspiro[4.5]decane derivatives
Fluorine-18
Positron emission tomography
σ(1) receptor
Journal
Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298
Informations de publication
Date de publication:
15 07 2020
15 07 2020
Historique:
received:
15
03
2020
revised:
12
05
2020
accepted:
16
05
2020
entrez:
4
7
2020
pubmed:
4
7
2020
medline:
13
5
2021
Statut:
ppublish
Résumé
We report the design, synthesis, and evaluation of a series of 1-oxa-8-azaspiro[4.5]decane and 1,5-dioxa-9-azaspiro[5.5]undecane derivatives as selective σ
Identifiants
pubmed: 32616183
pii: S0968-0896(20)30390-4
doi: 10.1016/j.bmc.2020.115560
pii:
doi:
Substances chimiques
1-oxa-8-azaspiro(4.5)decane
0
Aza Compounds
0
Fluorine Radioisotopes
0
Ligands
0
Receptors, sigma
0
Spiro Compounds
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
115560Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.