Research Note: Evaluation of deoxycholic acid for antihistomonal activity.
Histomonas meleagridis
blackhead
deoxycholic acid
histomoniasis
turkey
Journal
Poultry science
ISSN: 1525-3171
Titre abrégé: Poult Sci
Pays: England
ID NLM: 0401150
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
21
11
2019
revised:
20
03
2020
accepted:
21
03
2020
entrez:
4
7
2020
pubmed:
4
7
2020
medline:
3
2
2021
Statut:
ppublish
Résumé
Deoxycholic acid (DCA) is a naturally occurring secondary bile acid that originates from intestinal bacterial metabolic conversion of cholate, a primary bile acid. Deoxycholic acid was shown to have antihistomonal properties in vitro, leading to our hypothesis that DCA inclusion within the feed might prevent histomoniasis. Selected dietary concentrations of DCA were evaluated for effects on body weight gain (BWG), lesions, and mortality of turkeys challenged with wild-type Histomonas meleagridis (WTH). Treatments consisted of non-challenged control (NC; basal diet), 0.25% DCA diet + challenge, 0.5% DCA diet + challenge, 1% DCA diet + challenge, and a positive-challenged control (PC; basal diet). All groups were fed a basal starter diet until day 7, at which time DCA diets were administered to the respective groups. On day 14, 2 × 10
Identifiants
pubmed: 32616242
pii: S0032-5791(20)30225-X
doi: 10.1016/j.psj.2020.03.049
pmc: PMC7597822
pii:
doi:
Substances chimiques
Antiparasitic Agents
0
Deoxycholic Acid
005990WHZZ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3481-3486Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
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