Liver Stiffness Is Associated With Progression of Albuminuria in Adults With Type 2 Diabetes: Nonalcoholic Fatty Disease Cohort Study.
diabetes
diabète
elastography
liver stiffness
microalbuminuria
microalbuminurie
nonalcoholic fatty disease
rigidité hépatique
stéatose non alcoolique
élastographie
Journal
Canadian journal of diabetes
ISSN: 2352-3840
Titre abrégé: Can J Diabetes
Pays: Canada
ID NLM: 101148810
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
10
05
2019
revised:
12
02
2020
accepted:
10
03
2020
entrez:
4
7
2020
pubmed:
4
7
2020
medline:
27
4
2021
Statut:
ppublish
Résumé
Previous studies have shown the association between liver fibrosis and albuminuria. However, the effect of liver fibrosis on change in albuminuria is unclear. Thus, we investigated the effect of liver fibrosis on change in albuminuria in patients with type 2 diabetes. In this retrospective cohort study, we assessed 105 patients with type 2 diabetes concomitant with nonalcoholic fatty disease. A change in urinary albumin excretion (UAE) was defined as follows: change in UAE=(logarithm [UAE+1] at follow-up examination minus logarithm [UAE+1] at baseline examination) / follow-up duration (1 year in this study). Elastography was performed to assess controlled attenuation parameter (dB/m) and liver stiffness measurement (LSM; kPa) values. Mean (standard deviation) data were as follows: age, 63.3 (12.1) years; body mass index, 25.4 (4.3) kg/m Liver stiffness is an independent risk factor for the progression of albuminuria in patients with type 2 diabetes.
Identifiants
pubmed: 32616276
pii: S1499-2671(20)30077-0
doi: 10.1016/j.jcjd.2020.03.004
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
428-433Informations de copyright
Copyright © 2020 Canadian Diabetes Association. Published by Elsevier Inc. All rights reserved.