Dopamine D1 receptor availability is not associated with delusional ideation measures of psychosis proneness.
Delusional ideation
Dopamine D1
Positron emission tomography
Psychosis proneness
Journal
Schizophrenia research
ISSN: 1573-2509
Titre abrégé: Schizophr Res
Pays: Netherlands
ID NLM: 8804207
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
28
02
2020
revised:
25
05
2020
accepted:
01
06
2020
pubmed:
4
7
2020
medline:
19
5
2021
entrez:
4
7
2020
Statut:
ppublish
Résumé
The dopamine D1 receptor (D1R) is thought to play a role in psychosis and schizophrenia, however positron emission tomography studies comparing patients and controls have been inconsistent. To circumvent some of the limitations of clinical studies, such as antipsychotic exposure, an alternative approach is to examine subclinical psychotic symptoms within the general population, i.e. psychosis proneness traits. In this study, we investigated whether D1R availability is associated with delusional ideation in healthy controls, in four experiments, using [
Identifiants
pubmed: 32616361
pii: S0920-9964(20)30345-5
doi: 10.1016/j.schres.2020.06.001
pii:
doi:
Substances chimiques
Receptors, Dopamine D1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
175-184Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflicts of interest. SC has received grant support from AstraZeneca as co-investigator, and has served as speaker for Roche and Otsuka Pharmaceuticals. L.F. was, during the study, employed at the Precision Medicine and Genomics, IMED Biotech Unit at Karolinska Institutet.