A role for alternative splicing in circadian control of exocytosis and glucose homeostasis.

ARNTL Transcription Factors / genetics Alternative Splicing Animals CLOCK Proteins / genetics Cells, Cultured Circadian Clocks / genetics Death Domain Receptor Signaling Adaptor Proteins / genetics Exocytosis Glucose / metabolism Guanine Nucleotide Exchange Factors / genetics Guanylate Kinases / genetics Homeostasis Insulin Secretion / genetics Insulin-Secreting Cells / metabolism Islets of Langerhans / metabolism Male Mice, Inbred C57BL Nuclear Proteins / physiology Obesity / genetics Synaptosomal-Associated Protein 25 / genetics Transcription Factors / physiology
CASK MADD RNA sequencing SNAP25 THRAP3 alternative splicing circadian clock exocytosis insulin secretion transcriptomics

Journal

Genes & development
ISSN: 1549-5477
Titre abrégé: Genes Dev
Pays: United States
ID NLM: 8711660

Informations de publication

Date de publication:
01 08 2020
Historique:
received: 05 03 2020
accepted: 10 06 2020
pubmed: 4 7 2020
medline: 14 4 2021
entrez: 4 7 2020
Statut: ppublish

Résumé

The circadian clock is encoded by a negative transcriptional feedback loop that coordinates physiology and behavior through molecular programs that remain incompletely understood. Here, we reveal rhythmic genome-wide alternative splicing (AS) of pre-mRNAs encoding regulators of peptidergic secretion within pancreatic β cells that are perturbed in

Identifiants

DOI: 10.1101/gad.338178.120 PMID: 32616519 PMC: PMC7397853
pubmed: 32616519
pii: gad.338178.120
doi: 10.1101/gad.338178.120
pmc: PMC7397853
doi:

Substances chimiques

ARNTL Transcription Factors 0
Bmal1 protein, mouse 0
Death Domain Receptor Signaling Adaptor Proteins 0
Guanine Nucleotide Exchange Factors 0
Madd protein, mouse 0
Nuclear Proteins 0
Snap25 protein, mouse 0
Synaptosomal-Associated Protein 25 0
Thrap3 protein, mouse 0
Transcription Factors 0
CLOCK Proteins EC 2.3.1.48
Clock protein, mouse EC 2.3.1.48
CASK kinases EC 2.7.11.1
Guanylate Kinases EC 2.7.4.8
Glucose IY9XDZ35W2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1089-1105

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK090625
Pays : United States
Organisme : CIHR
Pays : Canada
Organisme : NHGRI NIH HHS
ID : R01 HG004659
Pays : United States
Organisme : NHLBI NIH HHS
ID : F32 HL143978
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL061322
Pays : United States
Organisme : NIAMS NIH HHS
ID : U54 AR052646
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113011
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008666
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008152
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS047726
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK050203
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG065988
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM144295
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK100814
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007169
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007909
Pays : United States
Organisme : NIDDK NIH HHS
ID : F30 DK116481
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL140938
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020595
Pays : United States
Organisme : NIDDK NIH HHS
ID : P60 DK020595
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG011412
Pays : United States

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2020 Marcheva et al.; Published by Cold Spring Harbor Laboratory Press.

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Auteurs

Biliana Marcheva (B)

Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

Mark Perelis (M)

Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.

Benjamin J Weidemann (BJ)

Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

Akihiko Taguchi (A)

Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

Haopeng Lin (H)

Department of Pharmacology, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.

Chiaki Omura (C)

Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

Yumiko Kobayashi (Y)

Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

Marsha V Newman (MV)

Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

Eugene J Wyatt (EJ)

Center for Genetic Medicine, Northwestern University, Chicago, Illinois 60611, USA.

Elizabeth M McNally (EM)

Center for Genetic Medicine, Northwestern University, Chicago, Illinois 60611, USA.

Jocelyn E Manning Fox (JEM)

Department of Pharmacology, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.

Heekyung Hong (H)

Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

Archana Shankar (A)

Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.

Emily C Wheeler (EC)

Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.

Kathryn Moynihan Ramsey (KM)

Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

Patrick E MacDonald (PE)

Department of Pharmacology, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.

Gene W Yeo (GW)

Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.

Joseph Bass (J)

Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Facteurs de transcription ARNTL › A role for alternative splicing in circadian...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Épissage des ARN › Épissage alternatif › A role for alternative splicing in circadian...
questionsmedicales.fr › Eucaryotes › Animaux › A role for alternative splicing in circadian...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Protéines CLOCK › A role for alternative splicing in circadian...
questionsmedicales.fr › Cellules › Cellules cultivées › A role for alternative splicing in circadian...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes chronobiologiques › Périodicité › Horloges biologiques › Horloges circadiennes › A role for alternative splicing in circadian...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Protéines adaptatrices de signalisation des récepteurs à domaine de mort › A role for alternative splicing in circadian...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Exocytose › A role for alternative splicing in circadian...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › A role for alternative splicing in circadian...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Facteurs d'échange de nucléotides guanyliques › A role for alternative splicing in circadian...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Phosphate Group Acceptor) › Guanylate kinase › A role for alternative splicing in circadian...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › A role for alternative splicing in circadian...
questionsmedicales.fr › Phénomènes physiologiques › Sécrétion d'insuline › A role for alternative splicing in circadian...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules entéroendocrines › Cellules à insuline › A role for alternative splicing in circadian...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Ilots pancréatiques › A role for alternative splicing in circadian...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › A role for alternative splicing in circadian...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › A role for alternative splicing in circadian...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › A role for alternative splicing in circadian...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Protéines SNARE › Protéines Q-SNARE › Protéines Qc-SNARE › Protéine SNAP-25 › A role for alternative splicing in circadian...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › A role for alternative splicing in circadian...