Immune status, and not HIV infection or exposure, drives the development of the oral microbiota.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
02 07 2020
02 07 2020
Historique:
received:
23
03
2020
accepted:
06
06
2020
entrez:
4
7
2020
pubmed:
4
7
2020
medline:
10
2
2021
Statut:
epublish
Résumé
Even with antiretroviral therapy, children born to HIV-infected (HI) mothers are at a higher risk of early-life infections and morbidities including dental disease. The increased risk of dental caries in HI children suggest immune-mediated changes in oral bacterial communities, however, the impact of perinatal HIV exposure on the oral microbiota remains unclear. We hypothesized that the oral microbiota of HI and perinatally HIV-exposed-but-uninfected (HEU) children will significantly differ from HIV-unexposed-and-uninfected (HUU) children. Saliva samples from 286 child-participants in Nigeria, aged ≤ 6 years, were analyzed using 16S rRNA gene sequencing. Perinatal HIV infection was significantly associated with community composition (HI vs. HUU-p = 0.04; HEU vs. HUU-p = 0.11) however, immune status had stronger impacts on bacterial profiles (p < 0.001). We observed age-stratified associations of perinatal HIV exposure on community composition, with HEU children differing from HUU children in early life but HEU children becoming more similar to HUU children with age. Our findings suggest that, regardless of age, HIV infection or exposure, low CD4 levels persistently alter the oral microbiota during this critical developmental period. Data also indicates that, while HIV infection clearly shapes the developing infant oral microbiome, the effect of perinatal exposure (without infection) appears transient.
Identifiants
pubmed: 32616727
doi: 10.1038/s41598-020-67487-4
pii: 10.1038/s41598-020-67487-4
pmc: PMC7331591
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
10830Subventions
Organisme : FIC NIH HHS
ID : D43 TW001041
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE025174
Pays : United States
Organisme : NIH HHS
ID : R01DE025174
Pays : United States
Organisme : FIC NIH HHS
ID : D43TW01041
Pays : United States
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