The colonic mucosa-associated microbiome in SIV infection: shift towards Bacteroidetes coincides with mucosal CD4
Animals
Bacterial Translocation
Bacteroidetes
/ classification
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes
/ immunology
Enterocytes
/ pathology
Firmicutes
/ isolation & purification
Gastrointestinal Microbiome
Helicobacter
/ isolation & purification
Intestinal Mucosa
/ microbiology
Macaca mulatta
Ribotyping
Simian Acquired Immunodeficiency Syndrome
/ immunology
Simian Immunodeficiency Virus
/ genetics
Viral Load
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
02 07 2020
02 07 2020
Historique:
received:
05
12
2019
accepted:
08
06
2020
entrez:
4
7
2020
pubmed:
4
7
2020
medline:
18
12
2020
Statut:
epublish
Résumé
The intesinal microbiome is considered important in human immunodeficiency virus (HIV) pathogenesis and therefore represents a potential therapeutic target to improve the patients' health status. Longitudinal alterations in the colonic mucosa-associated microbiome during simian immunodeficiency virus (SIV) infection were investigated using a 16S rRNA amplicon approach on the Illumina sequencing platform and bioinformatics analyses. Following SIV infection of six animals, no alterations in microbial composition were observed before the viral load peaked in the colon. At the time of acute mucosal SIV replication, the phylum Bacteroidetes including the Bacteroidia class as well as the phylum Firmicutes and its families Ruminococcaceae and Eubacteriaceae became more abundant. Enrichment of Bacteroidetes was maintained until the chronic phase of SIV infection. The shift towards Bacteroidetes in the mucosa-associated microbiome was associated with the extent of SIV infection-induced mucosal CD4
Identifiants
pubmed: 32616803
doi: 10.1038/s41598-020-67843-4
pii: 10.1038/s41598-020-67843-4
pmc: PMC7331662
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10887Références
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