Neurobiology of Recovery of Motor Function after Stroke: The Central Nervous System Biomarker Effects of Constraint-Induced Movement Therapy.
Journal
Neural plasticity
ISSN: 1687-5443
Titre abrégé: Neural Plast
Pays: United States
ID NLM: 100883417
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
01
2019
revised:
25
02
2019
accepted:
31
10
2019
entrez:
4
7
2020
pubmed:
4
7
2020
medline:
1
7
2021
Statut:
epublish
Résumé
Recovery of motor function after stroke involves many biomarkers. This review attempts to identify the biomarker effects responsible for recovery of motor function following the use of Constraint-Induced Movement Therapy (CIMT) and discuss their implications for research and practice. From the studies reviewed, the biomarker effects identified include improved perfusion of motor areas and brain glucose metabolism; increased expression of proteins, namely, Brain-Derived Neurotrophic Factor (BDNF), Vascular Endothelial Growth Factor (VEGF), and Growth-Associated Protein 43 (GAP-43); and decreased level of Gamma-Aminobutyric Acid (GABA). Others include increased cortical activation, increased motor map size, and decreased interhemispheric inhibition of the ipsilesional hemisphere by the contralesional hemisphere. Interestingly, the biomarker effects correlated well with improved motor function. However, some of the biomarker effects have not yet been investigated in humans, and they require that CIMT starts early on poststroke. In addition, one study seems to suggest the combined use of CIMT with other rehabilitation techniques such as Transcortical Direct Stimulation (tDCs) in patients with chronic stroke to achieve the biomarker effects. Unfortunately, there are few studies in humans that implemented CIMT during early poststroke. Thus, it is important that more studies in humans are carried out to determine the biomarker effects of CIMT especially early on poststroke, when there is a greater opportunity for recovery. Furthermore, it should be noted that these effects are mainly in ischaemic stroke.
Identifiants
pubmed: 32617098
doi: 10.1155/2020/9484298
pmc: PMC7312560
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
9484298Informations de copyright
Copyright © 2020 Auwal Abdullahi et al.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Cereb Blood Flow Metab. 2011 Mar;31(3):807-18
pubmed: 21157471
Stroke. 2006 Jul;37(7):1749-53
pubmed: 16763188
Stroke. 2000 Apr;31(4):946-54
pubmed: 10754004
Cogn Behav Neurol. 2006 Mar;19(1):41-7
pubmed: 16633018
Front Neurol. 2018 Aug 28;9:637
pubmed: 30210424
Nucl Med Mol Imaging. 2013 Jun;47(2):119-24
pubmed: 24900092
J Neurosci Res. 2008 Jun;86(8):1659-69
pubmed: 18189318
J Neurophysiol. 2006 Mar;95(3):1639-44
pubmed: 16221751
Exp Neurol. 2006 Oct;201(2):375-87
pubmed: 16828743
Neurorehabil Neural Repair. 2012 Sep;26(7):881-8
pubmed: 22396499
Stroke. 2008 May;39(5):1520-5
pubmed: 18323492
Brain Stimul. 2014 Nov-Dec;7(6):841-8
pubmed: 25458712
Neural Plast. 2013;2013:924192
pubmed: 23738150
Nat Med. 2003 Jun;9(6):677-84
pubmed: 12778166
Stroke. 2014 Jun;45(6):1881-6
pubmed: 24743441
Tohoku J Exp Med. 2009 Aug;218(4):301-8
pubmed: 19638734
Exp Brain Res. 2006 Feb;169(1):106-16
pubmed: 16273404
Front Neurol. 2016 May 17;7:69
pubmed: 27242654
Clin Pharmacol Ther. 2001 Mar;69(3):89-95
pubmed: 11240971
Exp Transl Stroke Med. 2016 Dec 7;8:9
pubmed: 27980710
Med Sci Monit. 2015 Dec 14;21:3900-5
pubmed: 26656843
PLoS One. 2016 Nov 15;11(11):e0166210
pubmed: 27846290
Neuroscience. 2015 Feb 12;286:316-24
pubmed: 25463522
Neurorehabil Neural Repair. 2008 Sep-Oct;22(5):505-13
pubmed: 18780885
J Rehabil Med. 2009 Mar;41(4):231-6
pubmed: 19247541
Curr Neurovasc Res. 2017;14(4):368-377
pubmed: 29189156
Neurorehabil Neural Repair. 2007 Jan-Feb;21(1):14-24
pubmed: 17172550
Restor Neurol Neurosci. 2004;22(3-5):269-77
pubmed: 15502271
Restor Neurol Neurosci. 2015;33(6):911-26
pubmed: 26484700
Int J Stroke. 2017 Jan;12(1):71-83
pubmed: 28004991
Neural Regen Res. 2015 Dec;10(12):2004-10
pubmed: 26889190
Mol Neurobiol. 2009 Feb;39(1):37-49
pubmed: 19156544
Sci Rep. 2016 Nov 29;6:37823
pubmed: 27897203
Stroke. 2000 May;31(5):1081-9
pubmed: 10797169
Brain. 2004 Apr;127(Pt 4):747-58
pubmed: 14749291
Neurorehabil Neural Repair. 2017 Jan;31(1):3-24
pubmed: 27503908
Circ Res. 2003 Nov 28;93(11):1074-81
pubmed: 14576200
Neurocase. 2006 Feb;12(1):50-60
pubmed: 16517515
J Cereb Blood Flow Metab. 2005 Dec;25(12):1668-74
pubmed: 15931162
Front Neurol. 2014 Jun 06;5:91
pubmed: 24936196
Arch Phys Med Rehabil. 2012 Oct;93(10):1846-55
pubmed: 22613094
Stroke. 1993 Dec;24(12):1784-8
pubmed: 8248955
Ann Neurol. 1994 Oct;36(4):557-65
pubmed: 7944288
Stroke. 2011 Mar;42(3):618-25
pubmed: 21257825
Stroke. 2007 Oct;38(10):2733-7
pubmed: 17717318
ASN Neuro. 2012 Jul 20;4(5):
pubmed: 22612861
Stroke. 2009 Apr;40(4):1490-5
pubmed: 19164786
Neurology. 2002 Jul 23;59(2):205-9
pubmed: 12136058
Brain. 2003 Jun;126(Pt 6):1430-48
pubmed: 12764063
Neurorehabil Neural Repair. 2011 Nov-Dec;25(9):819-29
pubmed: 21803933
Behav Neural Biol. 1985 Jan;43(1):3-11
pubmed: 3158299
Biochim Biophys Acta. 1991 Dec 10;1072(2-3):129-57
pubmed: 1751545
Eura Medicophys. 2006 Sep;42(3):257-68
pubmed: 17039224
Mayo Clin Proc. 1996 Aug;71(8):801-12
pubmed: 8691903
Neurosci Behav Physiol. 2000 Sep-Oct;30(5):491-5
pubmed: 11037137
Neurology. 2009 Jul 21;73(3):195-201
pubmed: 19458319
Chang Gung Med J. 2010 Nov-Dec;33(6):628-38
pubmed: 21199608
Mol Cell Endocrinol. 2014 Nov;397(1-2):51-8
pubmed: 25132648
Neural Regen Res. 2014 Apr 1;9(7):749-56
pubmed: 25206883
Neuroimage. 2011 Apr 1;55(3):1147-58
pubmed: 21238594
Curr Med Chem. 2009;16(34):4593-600
pubmed: 19903149
J Cereb Blood Flow Metab. 2014 Apr;34(4):630-7
pubmed: 24398938
J Physiol. 2009 Jan 15;587(1):11-2
pubmed: 18955377
Stroke. 2005 Nov;36(11):2493-6
pubmed: 16224078
J Neuropathol Exp Neurol. 2004 Jan;63(1):84-96
pubmed: 14748564
Neurologist. 2007 May;13(3):148-9
pubmed: 17495759
Front Hum Neurosci. 2014 Jun 27;8:378
pubmed: 25018714
Neural Regen Res. 2012 Nov 15;7(32):2548-53
pubmed: 25337108
Trends Neurosci. 2013 Oct;36(10):587-97
pubmed: 23968694
Pathophysiology. 2010 Jun;17(3):197-218
pubmed: 20074922
Eur J Neurol. 2012 Apr;19(4):578-86
pubmed: 22040308
Neurol Res Int. 2018 Apr 2;2018:5496408
pubmed: 29808120
Restor Neurol Neurosci. 2011;29(5):299-310
pubmed: 21697588
J Stroke. 2013 Sep;15(3):164-73
pubmed: 24396810
J Neurosci. 2006 May 31;26(22):6096-102
pubmed: 16738254
Neurosci Lett. 2015 Jun 15;597:176-82
pubmed: 25929184
Stroke. 2001 May;32(5):1140-6
pubmed: 11340223
Nat Rev Neurosci. 2013 Jan;14(1):7-23
pubmed: 23254191
Phys Ther. 2010 Mar;90(3):398-410
pubmed: 20110339
Front Hum Neurosci. 2017 May 18;11:265
pubmed: 28572764
Behav Brain Res. 2015 May 1;284:158-66
pubmed: 25700666
Front Neurol. 2015 Nov 11;6:238
pubmed: 26617568
Brain Res. 1999 Jul 17;835(1):10-7
pubmed: 10448191
Magn Reson Med. 2004 Aug;52(2):403-6
pubmed: 15282824
Eur J Neurosci. 2010 Oct;32(8):1239-44
pubmed: 20880359
Stroke. 2008 Oct;39(10):2837-44
pubmed: 18635857
Annu Rev Cell Dev Biol. 1999;15:551-78
pubmed: 10611972
Int J Stroke. 2017 Jul;12(5):480-493
pubmed: 28697711
Front Hum Neurosci. 2014 Jun 27;8:396
pubmed: 25018720
Brain Res Mol Brain Res. 2004 Dec 20;132(2):146-54
pubmed: 15582154
NeuroRehabilitation. 2014;35(3):415-26
pubmed: 25227542
Stroke. 2013 Jul;44(7):2064-89
pubmed: 23652265
Neurosci Lett. 1998 Jun 26;250(1):5-8
pubmed: 9696052
Am J Phys Med Rehabil. 2010 Mar;89(3):177-85
pubmed: 20173425
Ann Indian Acad Neurol. 2013 Jul;16(3):394-7
pubmed: 24101824
Brain. 2004 Jul;127(Pt 7):1670-7
pubmed: 15128622
Annu Rev Neurosci. 2000;23:393-415
pubmed: 10845069
Arch Phys Med Rehabil. 1993 Apr;74(4):347-54
pubmed: 8466415
J Neurosci. 2002 Sep 15;22(18):8133-8
pubmed: 12223567
Int J Mol Med. 2017 Jun;39(6):1338-1346
pubmed: 28440493
Curr Biol. 2011 Mar 22;21(6):480-4
pubmed: 21376596
Neurorehabil Neural Repair. 2015 Mar-Apr;29(3):278-86
pubmed: 25055837
Growth Factors. 2004 Sep;22(3):123-31
pubmed: 15518235
PLoS One. 2016 Mar 23;11(3):e0152241
pubmed: 27007747
Invest Radiol. 1998 Jun;33(6):336-40
pubmed: 9647445
Int J Rehabil Res. 2016 Sep;39(3):197-210
pubmed: 27123790
BMC Neurol. 2018 Dec 7;18(1):202
pubmed: 30526557
Molecules. 2010 Aug 02;15(8):5246-57
pubmed: 20714296
Circ Res. 1978 Nov;43(5):769-76
pubmed: 709741
Stroke. 2013 Jun;44(6):1698-705
pubmed: 23632976
Clin Neurophysiol. 2008 Oct;119(10):2175-6
pubmed: 18752992
Nat Med. 2002 Sep;8(9):963-70
pubmed: 12161747
J Neurol Neurosurg Psychiatry. 2004 Mar;75(3):353-61
pubmed: 14966145
Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7657-62
pubmed: 10861025
Eur J Phys Rehabil Med. 2015 Aug;51(4):371-9
pubmed: 25030204
Int Rev Cell Mol Biol. 2012;298:229-317
pubmed: 22878108
Int J Neurosci. 2018 Aug;128(8):736-745
pubmed: 29251083
Neural Regen Res. 2014 Dec 1;9(23):2026-8
pubmed: 25657711
Stroke. 2007 Jul;38(7):2165-72
pubmed: 17510456