Inhibitory Effect of Ursolic Acid on Ultraviolet B Radiation-Induced Oxidative Stress and Proinflammatory Response-Mediated Senescence in Human Skin Dermal Fibroblasts.
Caspase 3
/ metabolism
Cell Nucleus
/ drug effects
Cell Survival
/ drug effects
Cellular Senescence
/ drug effects
DNA Damage
Dermis
/ pathology
Fibroblasts
/ drug effects
Humans
Inflammation
/ pathology
Matrix Metalloproteinase 2
/ genetics
Matrix Metalloproteinase 9
/ genetics
Membrane Potential, Mitochondrial
/ drug effects
NF-kappa B
/ metabolism
Oxidative Stress
/ drug effects
RNA, Messenger
/ genetics
Reactive Oxygen Species
/ metabolism
Thiobarbituric Acid Reactive Substances
/ metabolism
Triterpenes
/ chemistry
Tumor Necrosis Factor-alpha
/ metabolism
Tumor Suppressor Protein p53
/ metabolism
Ultraviolet Rays
bcl-2-Associated X Protein
/ metabolism
Ursolic Acid
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2020
2020
Historique:
received:
09
03
2020
accepted:
21
05
2020
entrez:
4
7
2020
pubmed:
4
7
2020
medline:
7
2
2021
Statut:
epublish
Résumé
Ultraviolet radiation is an environmental carcinogenic agent that enhances inflammation and immunological reactions in the exposed human skin cells leading to oxidative photoaging of the epidermal and dermal segment. In the present study, we investigated the protective role of ursolic acid (UA) against ultraviolet B (UVB) radiation- induced photoaging an
Identifiants
pubmed: 32617130
doi: 10.1155/2020/1246510
pmc: PMC7313156
doi:
Substances chimiques
NF-kappa B
0
RNA, Messenger
0
Reactive Oxygen Species
0
Thiobarbituric Acid Reactive Substances
0
Triterpenes
0
Tumor Necrosis Factor-alpha
0
Tumor Suppressor Protein p53
0
bcl-2-Associated X Protein
0
Caspase 3
EC 3.4.22.-
Matrix Metalloproteinase 2
EC 3.4.24.24
Matrix Metalloproteinase 9
EC 3.4.24.35
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1246510Informations de copyright
Copyright © 2020 Ramachandran Samivel et al.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest.
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