Genotypic and allelic frequencies of
MDR1
breeding management
dogs
genetic analysis
ivermectint Toxicosisx
Journal
Veterinary record open
ISSN: 2052-6113
Titre abrégé: Vet Rec Open
Pays: United States
ID NLM: 101653671
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
10
2019
revised:
18
02
2020
accepted:
05
03
2020
entrez:
4
7
2020
pubmed:
4
7
2020
medline:
4
7
2020
Statut:
epublish
Résumé
A mutation in the canine multidrug resistance Genotype data for the 4-bp deletion (c296_299del4) in The mutated allele has been found in 9 out of 31 breeds: Rough Collie, Smooth Collie, Border Collie, Bearded Collie, Shetland Sheepdog, Australian Shepherd, White Swiss Shepherd, Old English Sheepdog, Whippet and also in crossbreed. The breeds with the highest allelic mutation frequency are Smooth and Rough Collies with 75 per cent and 66 per cent of mutant The results support the usefulness of this genetic analysis to optimise medical care in dogs at risk of multidrug resistance and to create an objective basis in breeding programme definition and in the risk evaluation in different breeds.
Sections du résumé
BACKGROUND
BACKGROUND
A mutation in the canine multidrug resistance
METHODS
METHODS
Genotype data for the 4-bp deletion (c296_299del4) in
RESULTS
RESULTS
The mutated allele has been found in 9 out of 31 breeds: Rough Collie, Smooth Collie, Border Collie, Bearded Collie, Shetland Sheepdog, Australian Shepherd, White Swiss Shepherd, Old English Sheepdog, Whippet and also in crossbreed. The breeds with the highest allelic mutation frequency are Smooth and Rough Collies with 75 per cent and 66 per cent of mutant
CONCLUSIONS
CONCLUSIONS
The results support the usefulness of this genetic analysis to optimise medical care in dogs at risk of multidrug resistance and to create an objective basis in breeding programme definition and in the risk evaluation in different breeds.
Identifiants
pubmed: 32617164
doi: 10.1136/vetreco-2019-000375
pii: vetreco-2019-000375
pmc: PMC7319724
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e000375Informations de copyright
© British Veterinary Association 2020. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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