Bone marrow metastasis of glioblastoma multiforme mimicking acute myeloid leukemia.
Journal
Oxford medical case reports
ISSN: 2053-8855
Titre abrégé: Oxf Med Case Reports
Pays: England
ID NLM: 101642070
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
29
04
2020
revised:
03
05
2020
accepted:
17
05
2020
entrez:
4
7
2020
pubmed:
4
7
2020
medline:
4
7
2020
Statut:
epublish
Résumé
A 46-year-old female patient with glioblastoma multiforme (GBM), IDH wild type developed severe pancytopenia 5 months after postoperative chemoradiotherapy. Bone marrow aspirate showed normocellular marrow with 70.0% abnormal cells, which suggested the possibility of acute myeloid leukemia. Immunophenotypic analysis did not show any hematological lineage markers, except for cluster of differentiation 56. The results of immunohistochemical staining of glial fibrillary acidic protein and oligodendrocyte transcription Factor 2 were positive. Based on these findings, the patient was diagnosed with bone marrow metastasis from GBM. Bone marrow metastasis from GBM is rare and little is known about the morphological characteristics of bone marrow aspiration smear findings. We experienced a rare case with marrow metastasis from GBM mimicking acute myeloid leukemia.
Identifiants
pubmed: 32617167
doi: 10.1093/omcr/omaa040
pii: omaa040
pmc: PMC7315933
doi:
Types de publication
Case Reports
Langues
eng
Pagination
omaa040Informations de copyright
© The Author(s) 2020. Published by Oxford University Press.
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