Cationic Versus Anionic Phthalocyanines for Photodynamic Therapy: What a Difference the Charge Makes.
Antineoplastic Agents
/ chemical synthesis
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Indoles
/ chemical synthesis
Light
Liposomes
/ chemistry
Molecular Structure
Phosphatidylcholines
/ chemistry
Photochemotherapy
Photosensitizing Agents
/ chemical synthesis
Serum Albumin, Bovine
/ metabolism
Singlet Oxygen
/ metabolism
Zinc
/ chemistry
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
23 07 2020
23 07 2020
Historique:
pubmed:
4
7
2020
medline:
15
12
2020
entrez:
4
7
2020
Statut:
ppublish
Résumé
The literature reports on cationic and anionic phthalocyanines (Pcs) for photodynamic therapy suggest systematically significant differences in activity. In this work, ten different zinc(II) Pcs with carboxylate functions or quaternary nitrogens (hydrophilic anionic, hydrophilic cationic, amphiphilic anionic, and amphiphilic cationic) were investigated, with the aim of revealing reasons for such differences.
Identifiants
pubmed: 32618190
doi: 10.1021/acs.jmedchem.0c00481
doi:
Substances chimiques
Antineoplastic Agents
0
Indoles
0
Liposomes
0
Phosphatidylcholines
0
Photosensitizing Agents
0
Singlet Oxygen
17778-80-2
Serum Albumin, Bovine
27432CM55Q
1,2-oleoylphosphatidylcholine
EDS2L3ODLV
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM