Selenium deficiency causes immune damage by activating the DUSP1/NF-κB pathway and endoplasmic reticulum stress in chicken spleen.
Animals
Chickens
Dual Specificity Phosphatase 1
/ genetics
Endoplasmic Reticulum Stress
/ genetics
Enzyme Activation
/ physiology
Gene Expression Regulation
Inflammation
/ genetics
Male
NF-kappa B
/ genetics
Poultry Diseases
/ etiology
Selenium
/ deficiency
Signal Transduction
/ physiology
Spleen
/ immunology
Splenic Diseases
/ genetics
T-Lymphocytes
/ immunology
Journal
Food & function
ISSN: 2042-650X
Titre abrégé: Food Funct
Pays: England
ID NLM: 101549033
Informations de publication
Date de publication:
01 Jul 2020
01 Jul 2020
Historique:
pubmed:
4
7
2020
medline:
4
6
2021
entrez:
4
7
2020
Statut:
ppublish
Résumé
Selenium (Se) is an essential trace element and its deficiency can lead to immune dysfunction. Many studies have investigated the immune damage caused by Se deficiency in chickens, but its mechanism still needs to be explored. In this study, we fed 1-day-old Hyline male chickens with Se deficient diets (the Se content was 0.008 mg kg
Substances chimiques
NF-kappa B
0
Dual Specificity Phosphatase 1
EC 3.1.3.48
Selenium
H6241UJ22B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM