Jiawei Shengmai San herbal formula ameliorates diabetic associate cognitive decline by modulating AKT and CREB in rats.
Animals
Brain
/ drug effects
Cognitive Dysfunction
/ etiology
Cyclic AMP Response Element-Binding Protein
/ metabolism
Diabetes Mellitus, Experimental
/ complications
Disease Models, Animal
Drug Combinations
Drugs, Chinese Herbal
/ chemistry
Male
Maze Learning
/ drug effects
Memory
/ drug effects
Memory Disorders
/ etiology
Phytotherapy
Proto-Oncogene Proteins c-akt
/ metabolism
Pueraria
/ chemistry
Rats
Rats, Sprague-Dawley
Signal Transduction
/ drug effects
Streptozocin
Morris water maze
diabetes-associated cognitive decline
protein kinase B (Akt) and cAMP response element binding protein (CREB)
reference and working memory
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
28
10
2019
revised:
02
05
2020
accepted:
24
05
2020
pubmed:
4
7
2020
medline:
20
1
2021
entrez:
4
7
2020
Statut:
ppublish
Résumé
Memory loss is a complication of diabetes which requires new approaches to its treatment. Shengmai San (SMS) is a famous traditional Chinese formula containing Panax ginseng, Ophiopogon japonicas, and Schisandra chinensis, whereas Radix puerariae has many reported pharmacological uses. In this study the combination, as Jiawei SMS (J-SMS) was screened for its ability to reverse diabetes-associated cognitive decline in rats. This was assessed behaviorally in diabetic rats (Streptozotocin, 45 mg/kg), with biochemical and western blot analysis (Akt and CREB). Diabetic rats showed fasting blood glucose (FBG) in the range of 13-15 mM throughout the study. J-SMS (0.5, 1.5, 4.5 g/kg) treatment significantly improved learning and memory deficit among diabetic rats as evidenced by preference for novel object, reduced escape latency and increased number of platform crossings (p < .05) in the NORT and MWM tests. Treatment with J-SMS also significantly improved the histopathological changes in the diabetic brain and increased the protein expression of AKT and CREB, required for proper memory function (p < .01). This study highlighted that J-SMS can reverse reference and working memory deficit among diabetic rats by modulating AKT and CREB proteins activation. Thus, J-SMS formulation might be possible candidate for further development.
Substances chimiques
Cyclic AMP Response Element-Binding Protein
0
Drug Combinations
0
Drugs, Chinese Herbal
0
fructus schizandrae, radix ginseng, radix ophiopogonis drug combination
0
Streptozocin
5W494URQ81
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3249-3261Subventions
Organisme : High-end Talents Recruitment Program (Chen Chen group) of Luzhou Municipal People's Government
Organisme : High-end Talents Recruitment Program (Liu Xinmin group) of Luzhou Municipal People's Government
Organisme : Office of Sciences & Technology and Talent work of Luzhou
ID : 2018LZXNY-ZK32
Organisme : Science & Technology Department of Sichuan province
ID : 2019YFH0023
Organisme : Sichuan Medical University Joint Project
ID : 2015LZCYD-S04(7/15
Organisme : Sichuan Provincial Sciences and Technology Department-Luzhou city
Organisme : National Key Research and Development Program of China
ID : 2016YFE0131800
Informations de copyright
© 2020 John Wiley & Sons, Ltd.
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