Arrhythmic Gut Microbiome Signatures Predict Risk of Type 2 Diabetes.

Bacteria / classification Circadian Clocks / physiology Circadian Rhythm / physiology Diabetes Mellitus, Type 2 / epidemiology Feces / microbiology Gastrointestinal Microbiome / genetics Germany / epidemiology Humans Metagenome / genetics Metagenomics / methods Obesity / microbiology

amplicon sequencing circadian rhythms diurnal oscillations human intestinal microbiota machine learning metagenomics obesity population-based cohorts prediction type 2 diabetes

Journal

Cell host & microbe

ISSN: 1934-6069

Titre abrégé: Cell Host Microbe

Pays: United States

ID NLM: 101302316

Informations de publication

Date de publication:
12 08 2020

Historique:

received: 23 02 2020

revised: 08 05 2020

accepted: 08 06 2020

pubmed: 4 7 2020

medline: 13 5 2021

entrez: 4 7 2020

Statut: ppublish

Résumé

Lifestyle, obesity, and the gut microbiome are important risk factors for metabolic disorders. We demonstrate in 1,976 subjects of a German population cohort (KORA) that specific microbiota members show 24-h oscillations in their relative abundance and identified 13 taxa with disrupted rhythmicity in type 2 diabetes (T2D). Cross-validated prediction models based on this signature similarly classified T2D. In an independent cohort (FoCus), disruption of microbial oscillation and the model for T2D classification was confirmed in 1,363 subjects. This arrhythmic risk signature was able to predict T2D in 699 KORA subjects 5 years after initial sampling, being most effective in combination with BMI. Shotgun metagenomic analysis functionally linked 26 metabolic pathways to the diurnal oscillation of gut bacteria. Thus, a cohort-specific risk pattern of arrhythmic taxa enables classification and prediction of T2D, suggesting a functional link between circadian rhythms and the microbiome in metabolic diseases.

Identifiants

DOI: 10.1016/j.chom.2020.06.004 PMID: 32619440

pubmed: 32619440

pii: S1931-3128(20)30343-7

doi: 10.1016/j.chom.2020.06.004

pii:

doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

258-272.e6

Subventions

Organisme : Medical Research Council

ID : MR/N030125/1

Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.