Translational Research in Culture: AADAC, Diabetes, and Cardiovascular Disease.

Animals Atherosclerosis Carboxylic Ester Hydrolases Cardiovascular Diseases Diabetes Mellitus, Type 2 Humans Induced Pluripotent Stem Cells Mice Muscle, Smooth, Vascular Myocytes, Smooth Muscle Translational Research, Biomedical

Journal

Cell stem cell
ISSN: 1875-9777
Titre abrégé: Cell Stem Cell
Pays: United States
ID NLM: 101311472

Informations de publication

Date de publication:
02 07 2020
Historique:
entrez: 4 7 2020
pubmed: 4 7 2020
medline: 25 2 2021
Statut: ppublish

Résumé

Many type 2 diabetes patients develop cardiovascular disease (CVD) while some are protected. Toyohara et al. (2020) find that elevated arylacetamide deacetylase (AADAC) expression in vascular smooth muscle cells (dVSMCs) differentiated from patient-derived induced pluripotent stem cells is associated with cardioprotection. AADAC overexpression alters multiple dVSMC properties and decreases murine CVD.

Identifiants

DOI: 10.1016/j.stem.2020.06.012 PMID: 32619519
pubmed: 32619519
pii: S1934-5909(20)30279-4
doi: 10.1016/j.stem.2020.06.012
pii:
doi:

Substances chimiques

AADAC protein, human EC 3.1.1.-
Carboxylic Ester Hydrolases EC 3.1.1.-

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

6-7

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Ashish Misra (A)

Heart Research Institute, Sydney, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. Electronic address: ashish.misra@hri.org.au.

Edward A Fisher (EA)

Department of Medicine/Divsion of Cardiology, and the Cardiovascular Research Center, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: edward.fisher@nyulangone.org.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Translational Research in Culture: AADAC,...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › Translational Research in Culture: AADAC,...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Translational Research in Culture: AADAC,...
questionsmedicales.fr › Maladies cardiovasculaires › Translational Research in Culture: AADAC,...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Translational Research in Culture: AADAC,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Translational Research in Culture: AADAC,...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches pluripotentes induites › Translational Research in Culture: AADAC,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Translational Research in Culture: AADAC,...
questionsmedicales.fr › Tissus › Muscles › Muscles lisses › Muscles lisses vasculaires › Translational Research in Culture: AADAC,...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes du muscle lisse › Translational Research in Culture: AADAC,...
questionsmedicales.fr › Disciplines des sciences naturelles › Science › Recherche › Recherche biomédicale › Recherche médicale translationnelle › Translational Research in Culture: AADAC,...