NBPF1 independently determine the risk stratification and prognosis of patients with neuroblastoma.

Carrier Proteins / genetics Female Humans Infant Male Mutation Neuroblastoma / genetics Prognosis RNA, Messenger / genetics Risk Survival Analysis
Bioinformatics NBPF1 Neuroblastoma Prognosis Risk stratification

Journal

Genomics
ISSN: 1089-8646
Titre abrégé: Genomics
Pays: United States
ID NLM: 8800135

Informations de publication

Date de publication:
11 2020
Historique:
received: 04 06 2020
accepted: 22 06 2020
pubmed: 4 7 2020
medline: 7 10 2021
entrez: 4 7 2020
Statut: ppublish

Résumé

Neuroblastoma is the most frequent extracranial malignant solid tumor in children, and the 5 year OS of high risk neuroblastoma patients was less than 15%. This study aimed to identify biomarkers for risk stratification and prognosis prediction in neuroblastoma.149 low risk samples, 108 intermediate risk samples and 619 high risk samples were included in our study, and NBPF1 gene was found to be significantly correlated with risk levels and OS. Significant negative correlations between NBPF1 and the expression of MYCN and AKT1S1, and positive correlations between NBPF1 and KIF1B expression were found, but only NBPF1 was an independent biomarker based on the construct of PPI for MYCN, NBPF1, KIF1B and AKT1S1 by STRING enrichment.

Identifiants

DOI: 10.1016/j.ygeno.2020.06.038 PMID: 32619576
pubmed: 32619576
pii: S0888-7543(20)30713-8
doi: 10.1016/j.ygeno.2020.06.038
pii:
doi:

Substances chimiques

Carrier Proteins 0
NBPF1 protein, human 0
RNA, Messenger 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3951-3957

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Jing Zhang (J)

Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China.

Yuanyuan Zhao (Y)

Department of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China.

Jianhua Wang (J)

Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China.

Tal Sneh (T)

Center for Molecular Design and Biomimetics, The Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA.

Qianqian Yu (Q)

Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China.

Xiao Zhou (X)

Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China.

Chen Gong (C)

Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China. Electronic address: chengong@tjh.tjmu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › NBPF1 independently determine the risk...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › NBPF1 independently determine the risk...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › NBPF1 independently determine the risk...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › NBPF1 independently determine the risk...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Tumeurs neuroectodermiques primitives › Tumeurs neuroectodermiques primitives périphériques › Neuroblastome › NBPF1 independently determine the risk...
questionsmedicales.fr › Diagnostic › Pronostic › NBPF1 independently determine the risk...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › NBPF1 independently determine the risk...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › NBPF1 independently determine the risk...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › NBPF1 independently determine the risk...