Update on Müller glia regenerative potential for retinal repair.
Journal
Current opinion in genetics & development
ISSN: 1879-0380
Titre abrégé: Curr Opin Genet Dev
Pays: England
ID NLM: 9111375
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
31
01
2020
revised:
08
05
2020
accepted:
24
05
2020
pubmed:
4
7
2020
medline:
3
7
2021
entrez:
4
7
2020
Statut:
ppublish
Résumé
Retinal regeneration efficiency from Müller glia varies tremendously among vertebrate species, being extremely limited in mammals. Efforts towards the identification of molecular mechanisms underlying Müller cell proliferative and neurogenic potential should help finding strategies to awake them and ensure regeneration in mammals. We provide here an update on the most recent and original progresses made in the field. These include remarkable discoveries regarding (i) unprecedented cross-species comparison of Müller cell transcriptome using single-cell technologies, (ii) the identification of new strategies to promote both the proliferative and the neurogenic potential of mammalian Müller cells, (iii) the role of the epigenome in regulating Müller glia plasticity, (iv) miRNA-based regulatory mechanisms of Müller cell response to injury, and (v) the influence of inflammatory signals on the regenerative process.
Identifiants
pubmed: 32619816
pii: S0959-437X(20)30076-9
doi: 10.1016/j.gde.2020.05.025
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
52-59Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.