Xeno-organ donor pigs with multiple genetic modifications - the more the better?

Animals Animals, Genetically Modified / genetics Gene Editing Genetic Engineering Swine Tissue Donors / supply & distribution Transplantation, Heterologous / methods

Journal

Current opinion in genetics & development
ISSN: 1879-0380
Titre abrégé: Curr Opin Genet Dev
Pays: England
ID NLM: 9111375

Informations de publication

Date de publication:
10 2020
Historique:
received: 14 03 2020
accepted: 25 05 2020
pubmed: 4 7 2020
medline: 3 7 2021
entrez: 4 7 2020
Statut: ppublish

Résumé

The number of donated human organs and tissues for patients with terminal organ failure falls far short of the need. Alternative sources, such as organs and tissues from animals, are therefore urgently required. During the past few years, major progress has been made in the development of genetically multi-modified donor pigs, and their organs have been shown to be safe and efficacious in life-supporting transplantation models into non-human primates, paving the way to clinical xenotransplantation studies. Here, we summarize recent developments in pig genome engineering and discuss efforts to develop the optimum donor pig for xenotransplantation. In addition, we speculate on how many genetic modifications may be required for initial xenotransplantation clinical trials.

Identifiants

DOI: 10.1016/j.gde.2020.05.034 PMID: 32619817
pubmed: 32619817
pii: S0959-437X(20)30085-X
doi: 10.1016/j.gde.2020.05.034
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

60-65

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Elisabeth Kemter (E)

Chair of Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany; Center for Innovative Medical Models (CiMM), Department of Veterinary Sciences, LMU Munich, 85764 Oberschleißheim, Germany.

Angelika Schnieke (A)

Chair of Livestock Biotechnology, School of Life Sciences Weihenstephan, Technische Universität München, 85350 Freising, Germany.

Konrad Fischer (K)

Chair of Livestock Biotechnology, School of Life Sciences Weihenstephan, Technische Universität München, 85350 Freising, Germany.

Peter J Cowan (PJ)

Immunology Research Centre, St. Vincent's Hospital Melbourne, and Department of Medicine, University of Melbourne, Victoria, Australia.

Eckhard Wolf (E)

Chair of Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany; Center for Innovative Medical Models (CiMM), Department of Veterinary Sciences, LMU Munich, 85764 Oberschleißheim, Germany. Electronic address: ewolf@genzentrum.lmu.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Xeno-organ donor pigs with multiple genetic...
questionsmedicales.fr › Stades d'organismes › Organismes génétiquement modifiés › Animal génétiquement modifié › Xeno-organ donor pigs with multiple genetic...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Édition de gène › Xeno-organ donor pigs with multiple genetic...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Xeno-organ donor pigs with multiple genetic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Xeno-organ donor pigs with multiple genetic...
questionsmedicales.fr › Personnes › Donneurs de tissus › Xeno-organ donor pigs with multiple genetic...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation hétérologue › Xeno-organ donor pigs with multiple genetic...