The influence of biomechanical stability on bone healing and fracture-related infection: the legacy of Stephan Perren.

Animals Biomechanical Phenomena Fracture Healing Fractures, Bone Humans

Journal

Injury
ISSN: 1879-0267
Titre abrégé: Injury
Pays: Netherlands
ID NLM: 0226040

Informations de publication

Date de publication:
Jan 2021
Historique:
received: 07 05 2020
revised: 16 06 2020
accepted: 24 06 2020
pubmed: 6 7 2020
medline: 22 6 2021
entrez: 5 7 2020
Statut: ppublish

Résumé

Bone healing is a complicated process of tissue regeneration that is influenced by multiple biological and biomechanical processes. In a minority of cases, these physiological processes are complicated by issues such as nonunion and/or fracture-related infection (FRI). Based on a select few in vivo experimental animal studies, construct stability is considered an important factor influencing both prevention and treatment of FRI. Stephan Perren played a pivotal role in the evolution of our current understanding of the critical relationship between biomechanics, fracture healing and infection. Furthermore, his concept of strain theory and the process of fracture healing is familiar to several generations of surgeons and has influenced implant development and design for the past 50 years. In this review we describe the role of biomechanical stability on fracture healing, and provide a detailed analysis of the preclinical studies addressing this in the context of FRI. Furthermore, we demonstrate how Perren's concepts of stability are still applied to current surgical techniques to aid in the prevention and treatment of FRI. Finally, we highlight the key knowledge gaps in the underlying basic research literature that need to be addressed as we continue to optimize patient care.

Identifiants

DOI: 10.1016/j.injury.2020.06.044 PMID: 32620328
pubmed: 32620328
pii: S0020-1383(20)30551-9
doi: 10.1016/j.injury.2020.06.044
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

43-52

Informations de copyright

Copyright © 2020. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of Competing Interest All authors declare no conflict of interest with respect to the preparation and writing of this article.

Auteurs

Andrew L Foster (AL)

AO Research Institute Davos, Davos, Switzerland; Queensland University of Technology, Brisbane, Australia; Department of Orthopaedic Surgery, Royal Brisbane and Women's Hospital, Australia; Jamieson Trauma Institute, Royal Brisbane and Women's Hospital, Australia.

T Fintan Moriarty (TF)

AO Research Institute Davos, Davos, Switzerland.

Charalampos Zalavras (C)

Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, USA.

Mario Morgenstern (M)

Department of Orthopedic and Trauma Surgery, Basel, Switzerland.

Anjali Jaiprakash (A)

Queensland University of Technology, Brisbane, Australia.

Ross Crawford (R)

Queensland University of Technology, Brisbane, Australia.

Marc-Antoine Burch (MA)

AO Research Institute Davos, Davos, Switzerland; Department of Orthopedic and Trauma Surgery, Basel, Switzerland.

Willemijn Boot (W)

AO Research Institute Davos, Davos, Switzerland.

Kevin Tetsworth (K)

Department of Orthopaedic Surgery, Royal Brisbane and Women's Hospital, Australia; Jamieson Trauma Institute, Royal Brisbane and Women's Hospital, Australia.

Theodore Miclau (T)

Department of Orthopaedic Surgery, University of California, San Francisco, Orthopaedic Trauma Institute, Zuckerberg San Francisco General Hospital, San Francisco, California, USA.

Peter Ochsner (P)

Medical University Basel, Switzerland.

Michael A Schuetz (MA)

AO Research Institute Davos, Davos, Switzerland; Department of Orthopaedic Surgery, Royal Brisbane and Women's Hospital, Australia; Jamieson Trauma Institute, Royal Brisbane and Women's Hospital, Australia.

R Geoff Richards (RG)

AO Research Institute Davos, Davos, Switzerland.

Willem-Jan Metsemakers (WJ)

Department of Trauma Surgery, University Hospital Leuven, Belgium; Department of Development and Regeneration, KU Leuven, Belgium. Electronic address: willem-jan.metsemakers@uzleuven.be.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The influence of biomechanical stability on...
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Phénomènes biomécaniques › The influence of biomechanical stability on...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Cicatrisation de plaie › Consolidation de fracture › The influence of biomechanical stability on...
questionsmedicales.fr › Plaies et blessures › Fractures osseuses › The influence of biomechanical stability on...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The influence of biomechanical stability on...